Presber W, Herrmann D K, Hegenscheid B
Institut für Medizinische Mikrobiologie des Bereiches Medizin (Charité), Humboldt-Universität zu Berlin, BRD.
Angew Parasitol. 1991 Feb;32(1):7-9.
Often existing cross-resistance to structure analogous antimalarials causes the need to find new active compounds against malaria parasites. For this purpose the traditional medicine of tropical countries has proved to be a treasury. A root extract of Cochlospermum angolense showed in vitro a remarkable activity against Plasmodium berghei in the DNA synthesis measurement with 3H-labelled hypoxanthine. This effect could be reproduced under in vivo conditions with the "4-day suppressive test" of rodent malaria.
现有的对结构类似抗疟药的交叉耐药性常常使得有必要寻找针对疟原虫的新型活性化合物。为此，热带国家的传统药物已被证明是一座宝库。在利用3H标记次黄嘌呤进行的DNA合成测量中，安哥拉柯桠树根提取物在体外显示出对伯氏疟原虫的显著活性。在啮齿动物疟疾的“4天抑制试验”的体内条件下，这种效应能够重现。
