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“单一毒理学”、“生态系统健康”和“同一健康”。

'One toxicology', 'ecosystem health' and 'one health'.

作者信息

Beasley Val

机构信息

Diplomate, American Board of Veterinary Toxicology, Professor of Veterinary, Wildlife and Ecological Toxicology, Department of Veterinary Biosciences, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 2001 South Lincoln Avenue, Urbana, Illinois 61802, USA.

出版信息

Vet Ital. 2009 Jan-Mar;45(1):97-110.

Abstract

'One Health' as a discipline links human and veterinary medicine as co-equal partners in an increasingly efficient joint venture into health promotion and prioritised research. 'One Toxicology' is proposed as a way to reunify toxicology as a component of 'Ecosystem Health' and the encompassing 'One Health'. Ecotoxicology, which includes wild animal, plant and microbial communities, is a critical component of 'Ecosystem Health'. 'One Toxicology' is proposed to help hold toxicological sciences together and maintain intimate connections to medicine in general. 'One Toxicology' is efficient because biochemical systems are highly conserved and, thus, when one group of species is at risk, other groups of species are also often at risk. Fortunately, in the case of toxicological risk, problems can be avoided, because humans can minimise exposures. Historically, human health has benefited immensely from studies of the impacts of chemicals on laboratory animals and wildlife. Similarly, veterinarians and wildlife managers have learned from careless or accidental poisonings of humans to protect the health of both domestic and wild animals. Yet, newly discovered emerging toxicoses abound, and well-known toxicoses persist - to the detriment of all life forms, including our own. Thus, in the 'One Toxicology' of the future, disciplinary boundaries should more rapidly blur. If this is done well, physicians, various public health specialists, veterinarians of many disciplines, wildlife health specialists, ecologists and an array of toxicologists will share and rely upon disparate sources of information with increasing efficiency to facilitate diagnosis and management of poisoning; to prevent unwanted, unwise, and unnecessary toxic injury to human, animal, plant, and microbial components of biodiversity; to decrease nutrients available that enable toxigenic species; and to prevent releases of chemical contaminants that indirectly set the stage for infectious diseases.

摘要

“同一健康”作为一门学科,将人类医学和兽医学视为同等重要的合作伙伴,共同开展一项日益高效的促进健康和重点研究的联合事业。“同一毒理学”被提议作为一种将毒理学重新统一为“生态系统健康”以及涵盖性的“同一健康”的一个组成部分的方式。生态毒理学包括野生动物、植物和微生物群落,是“生态系统健康”的关键组成部分。提议“同一毒理学”有助于将毒理学各学科整合在一起,并总体上保持与医学的紧密联系。“同一毒理学”之所以高效,是因为生物化学系统高度保守,因此,当一组物种面临风险时,其他物种组通常也面临风险。幸运的是,就毒理学风险而言,问题是可以避免的,因为人类可以尽量减少接触。从历史上看,化学物质对实验动物和野生动物影响的研究使人类健康受益匪浅。同样,兽医和野生动物管理者也从人类的粗心或意外中毒事件中吸取教训,以保护家养动物和野生动物的健康。然而,新发现的新出现的中毒病例层出不穷,而且众所周知的中毒病例仍然存在——这对包括我们自己在内的所有生命形式都造成了损害。因此,在未来 的“同一毒理学”中,学科界限应更快地模糊。如果做得好,医生、各类公共卫生专家、众多学科的兽医、野生动物健康专家、生态学家和一系列毒理学家将越来越高效地共享并依赖不同的信息来源,以促进中毒的诊断和管理;防止对生物多样性的人类、动物、植物和微生物成分造成不必要、不明智和不必要的毒性伤害;减少使产毒物种得以滋生的可用养分;并防止化学污染物的释放,这些污染物间接为传染病埋下伏笔。

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