类固醇激素对I型环磷酸腺苷依赖性蛋白激酶全酶量的特异性调节。
Specific regulation by steroid hormones of the amount of type I cyclic AMP-dependent protein kinase holoenzyme.
作者信息
Fuller D J, Byus C V, Russell D H
出版信息
Proc Natl Acad Sci U S A. 1978 Jan;75(1):223-7. doi: 10.1073/pnas.75.1.223.
Abstract
The total amounts of type I and type II cytoplasmic cyclic AMP-dependent protein kinase activities were measured in various tissues of intact rats and rats subjected to castration, hypophysectomy, or adrenalectomy. After castration, the total amount of type I activity decreased rapidly in classifically steroid-responsive tissues such as the ventral prostate and levator ani muscle and less rapidly in the liver. After hypophysectomy and adrenalectomy, type I activity in the liver decreased to the same extent as after castration. Type I activity could be maintained in the ventral prostate and levator ani muscle at control levels by the daily injection of dihydrotestosterone. Furthermore, after post-castration regression of the prostate for 3 days, three daily subcutaneous injections of dihydrotestosterone resulted in a complete restoration of type I activity toe the intact level. The amount of type II activity was not altered by any of the experimental ablations. This study provides evidence linking steroid action to the ability of steroid-responsive tissues to maintain a substantial activity of type I cyclic AMP-dependent protein kinase.
摘要
在完整大鼠以及接受去势、垂体切除或肾上腺切除的大鼠的各种组织中，测量了I型和II型细胞质环磷酸腺苷依赖性蛋白激酶的总活性。去势后，在典型的类固醇反应性组织如腹侧前列腺和提肛肌中，I型活性总量迅速下降，而在肝脏中下降较慢。垂体切除和肾上腺切除后，肝脏中的I型活性下降程度与去势后相同。通过每日注射二氢睾酮，腹侧前列腺和提肛肌中的I型活性可维持在对照水平。此外，在前列腺去势后消退3天，每日皮下注射三次二氢睾酮可使I型活性完全恢复到完整水平。II型活性的量不受任何实验性切除的影响。本研究提供了证据，将类固醇作用与类固醇反应性组织维持I型环磷酸腺苷依赖性蛋白激酶大量活性的能力联系起来。
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