Johnson G B
Proc Natl Acad Sci U S A. 1978 Jan;75(1):395-9. doi: 10.1073/pnas.75.1.395.
Wild populations of Drosophila mojavensis exhibit considerable conformational variation in the NAD+-free form of alcohol dehydrogenase (alcohol:NAD+ oxidoreductase; EC 1.1.1.1). The variation appears genetic, as it does not occur within an inbred strain. The NAD+-bound form of alcohol dehydrogenase, present in the same individuals, does not exhibit the variation, suggesting that the binding of NAD+ acts to stabilize conformation. Such cofactor binding to enzymes may thus conceal considerable variation. A similar effect is suggested for binding of esterase subunits.
野生的莫哈韦果蝇种群中，无NAD⁺形式的乙醇脱氢酶（乙醇：NAD⁺氧化还原酶；EC 1.1.1.1）呈现出相当大的构象变异。这种变异似乎是遗传性的，因为在近交系中不会出现。同一果蝇个体中存在的与NAD⁺结合的乙醇脱氢酶形式并未表现出这种变异，这表明NAD⁺的结合起到稳定构象的作用。因此，这种辅因子与酶的结合可能掩盖了相当大的变异。酯酶亚基的结合也有类似的作用。
