Day T H, Buckley P A
Biochem Genet. 1980 Aug;18(7-8):727-42. doi: 10.1007/BF00484589.
Seaweed flies (Coelopa frigida) inhabit piles of decaying seaweed on the seashore. All populations so far studied have been found to be polymorphic at the alcohol dehydrogenase locus (Adh). This article reports an attempt to identify some of the forces of natural selection that may be maintaining this polymorphism First, the genetic determination of the rather complex isozyme system is described. Several inbred lines homozygous at the Adh locus were derived and the biochemical properties of their allozymes compared. Significant differences in both specific activities and thermal stabilities were found between ADH allozymes. A simple experiment is reported in which individuals with different Adh genotypes were cultured in competition with each other in the presence of elevated levels of ethanol. Although the presence of ethanol resulted in greater mortality, there is no evidence that it was selective with respect to the Adh genotypes. The possible relevance of these results to the maintenance of the Adh polymorphism is discussed.
海草蝇（Coelopa frigida）栖息在海岸边腐烂的海草堆中。到目前为止，所有已研究的种群在乙醇脱氢酶基因座（Adh）上都呈现出多态性。本文报告了一项旨在识别可能维持这种多态性的一些自然选择力量的尝试。首先，描述了相当复杂的同工酶系统的遗传决定因素。获得了几个在Adh基因座上纯合的近交系，并比较了它们的等位酶的生化特性。在ADH等位酶之间发现了比活性和热稳定性方面的显著差异。报告了一个简单的实验，其中具有不同Adh基因型的个体在乙醇水平升高的情况下相互竞争培养。尽管乙醇的存在导致了更高的死亡率，但没有证据表明它对Adh基因型具有选择性。讨论了这些结果与维持Adh多态性的可能相关性。
