Department of Endocrinology and Metabolism, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey.
BJU Int. 2010 Nov;106(9):1357-61. doi: 10.1111/j.1464-410X.2010.09348.x.
To evaluate female sexual dysfunction (FSD) in obese women in comparison with age-matched control group, emphasising their hormonal and psychological status.
PATIENTS, SUBJECTS AND METHODS: Sixty-four sexually active obese premenauposal women were compared with a control group of 27 age-matched healthy volunteers with a normal body mass index (BMI). The obese group was evaluated in three categories according to BMI (kg/m(2)), as group 1 (30-34.9), group 2 (35-39.9) and group 3 (> 40). All women were evaluated with Female Sexual Function Index (FSFI) questionnaire and Beck Depression Inventory (BDI). In addition, serum levels of follicle-stimulating hormone, luteinizing hormone, prolactin, dehydroepiandrosterone-SO(4) , free testosterone, 17α-hydroxyprogestrone, androstenedione, oestradiol, free thyroxine and thyrotropin were determined.
The mean FSFI scores were not statistically significant between control and obese patients (P = 0.29). FSD was diagnosed in 50% (32/64) and 41% (11/27) of the patients in the obese and control groups, respectively (P = 0.34). There were no differences between total FSFI and FSFI domain scores among BMI categories. BDI scores were significantly higher in the obese groups than in healthy controls, and negatively correlated with total FSFI and all FSFI domain scores. Among hormonal analyses, only free testosterone levels were negatively correlated with total FSFI scores.
This study showed that obesity has no significant relationship with FSD, but obese patients were found to be in a more depressive mood than age-matched normal counterparts.
评估肥胖女性的性功能障碍（FSD），并与年龄匹配的对照组进行比较，强调其激素和心理状况。
患者、受试者和方法：将 64 名有性生活的肥胖拟青春期前女性与 27 名年龄匹配的健康志愿者（BMI 正常）对照组进行比较。根据 BMI（kg/m²），肥胖组分为 3 组：组 1（30-34.9）、组 2（35-39.9）和组 3（>40）。所有女性均使用女性性功能指数（FSFI）问卷和贝克抑郁量表（BDI）进行评估。此外，还测定了血清卵泡刺激素、黄体生成素、催乳素、脱氢表雄酮-SO（4）、游离睾酮、17α-羟孕酮、雄烯二酮、雌二醇、游离甲状腺素和促甲状腺素水平。
对照组和肥胖患者的平均 FSFI 评分无统计学差异（P=0.29）。肥胖组和对照组分别有 50%（32/64）和 41%（11/27）的患者诊断为 FSD（P=0.34）。BMI 类别之间的总 FSFI 和 FSFI 域评分无差异。肥胖组的 BDI 评分明显高于健康对照组，且与总 FSFI 和所有 FSFI 域评分呈负相关。在激素分析中，只有游离睾酮水平与总 FSFI 评分呈负相关。
本研究表明肥胖与 FSD 无显著关系，但肥胖患者的抑郁情绪较年龄匹配的正常对照组更为严重。
