2009 年 9 月，两名从马尔代夫返回的德国游客感染基孔肯雅热。

Chikungunya fever in two German tourists returning from the Maldives, September, 2009.

机构信息

Institute of Animal Hygiene and Veterinary Public Health, Veterinary Faculty, University of Leipzig, Germany.

出版信息

Euro Surveill. 2010 Apr 1;15(13):19531.

PMID:20394712

Abstract

This report describes the first isolation and molecular characterisation of a chikungunya virus from two German tourists who became ill after a visit to the Maldives in September 2009. The virus contained the E1 A226V mutation, shown to be responsible for an adaptation to the Asian tiger mosquito Aedes albopictus. The E1 coding sequence was identical to chikungunya virus isolates from Sri Lanka and showed three nt-mismatches to the only available E1 nt sequence from the Maldives.

摘要

本报告描述了 2009 年 9 月两名德国游客在马尔代夫旅行后患病，从他们身上分离出的第一株基孔肯雅病毒，并对其进行了分子特征分析。该病毒含有 E1 A226V 突变，这种突变被认为是对亚洲虎蚊（Aedes albopictus）的适应。E1 编码序列与来自斯里兰卡的基孔肯雅病毒分离株完全相同，与唯一可用的来自马尔代夫的 E1 核苷酸序列有 3 个核苷酸不匹配。