Toll样受体：机械通气、固有免疫与肺损伤之间的联系？ - Suppr

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Toll-like receptors: a link between mechanical ventilation, innate immunity and lung injury?

作者信息

Charles Pierre Emmanuel, Barbar Saber Davide

出版信息

Intensive Care Med. 2010 Jun;36(6):909-11. doi: 10.1007/s00134-010-1804-x. Epub 2010 Apr 16.

DOI:10.1007/s00134-010-1804-x

PMID:20397010

Abstract

摘要

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Toll-like receptors: a link between mechanical ventilation, innate immunity and lung injury?Toll样受体：机械通气、固有免疫与肺损伤之间的联系？

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Mild-stretch mechanical ventilation upregulates toll-like receptor 2 and sensitizes the lung to bacterial lipopeptide.轻度伸展机械通气上调 Toll 样受体 2 并使肺对细菌脂肽敏感。

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本文引用的文献

Mechanical ventilation modulates Toll-like receptor signaling pathway in a sepsis-induced lung injury model.机械通气调控脓毒症诱导肺损伤模型中 Toll 样受体信号通路。

Intensive Care Med. 2010 Jun;36(6):1049-57. doi: 10.1007/s00134-010-1799-3. Epub 2010 Apr 16.

Crit Care Med. 2010 Jan;38(1):194-201. doi: 10.1097/CCM.0b013e3181bc7c17.

Protection from lethal gram-negative bacterial sepsis by targeting Toll-like receptor 4.通过靶向Toll样受体4预防致死性革兰氏阴性菌败血症

Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2348-52. doi: 10.1073/pnas.0808146106. Epub 2009 Jan 30.

Low-tidal-volume mechanical ventilation induces a toll-like receptor 4-dependent inflammatory response in healthy mice.低潮气量机械通气在健康小鼠中诱导一种Toll样受体4依赖性炎症反应。

Anesthesiology. 2008 Sep;109(3):465-72. doi: 10.1097/ALN.0b013e318182aef1.

TLR4-induced IFN-gamma production increases TLR2 sensitivity and drives Gram-negative sepsis in mice.Toll样受体4（TLR4）诱导的γ干扰素产生增加Toll样受体2（TLR2）敏感性并引发小鼠革兰氏阴性菌败血症。

J Exp Med. 2008 Aug 4;205(8):1747-54. doi: 10.1084/jem.20071990. Epub 2008 Jul 21.

Cyclic stretch of human lung cells induces an acidification and promotes bacterial growth.

Am J Respir Cell Mol Biol. 2008 Mar;38(3):362-70. doi: 10.1165/rcmb.2007-0114OC. Epub 2007 Oct 5.

Brief, large tidal volume ventilation initiates lung injury and a systemic response in fetal sheep.短暂的大潮气量通气会引发胎羊的肺损伤和全身反应。

Am J Respir Crit Care Med. 2007 Sep 15;176(6):575-81. doi: 10.1164/rccm.200701-051OC. Epub 2007 Jul 19.

Stress molecules in sepsis and systemic inflammatory response syndrome.脓毒症和全身炎症反应综合征中的应激分子

FEBS Lett. 2007 Jul 31;581(19):3723-33. doi: 10.1016/j.febslet.2007.03.074. Epub 2007 Apr 4.

Regulation of lung injury and repair by Toll-like receptors and hyaluronan.Toll样受体与透明质酸对肺损伤及修复的调控

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Modulation of lipopolysaccharide-induced gene transcription and promotion of lung injury by mechanical ventilation.机械通气对脂多糖诱导的基因转录的调节作用及对肺损伤的促进作用。

J Immunol. 2005 Sep 1;175(5):3369-76. doi: 10.4049/jimmunol.175.5.3369.

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