Faculte des Sciences de Monastir, Laboratoire de Chimie des Substances Naturelles et de Synthese Organique (99/UR/12-26), Universite de Monastir, Monastir, Tunisie.
Nat Prod Res. 2010 Apr;24(6):491-9. doi: 10.1080/14786410802228520.
The present work describes the chemical composition and evaluates the antibacterial and the antioxidant properties of root oil from Ridolfia segetum, a traditional medicinal plant widely distributed in Tunisia. The essential oil, analysed by combination of GC, GC/MS and (13)C-NMR, was dominated by dillapiole (47.4%) and myristicin (19.2%). The antioxidant potential of the essential oil was evaluated using the 2,2'-diphenyl-1-picrylhydrazyl free radical scavenging method. The phenylpropanoid-rich root oil possesses good antioxidant properties (IC(50) = 38 mg mL(-1)). The essential oil was evaluated for its antibacterial activity using the microdilution assay, resulting in the inhibition of a number of common human pathogenic bacteria as well as of some clinical and environmental isolated strains. The minimum inhibitory concentrations of the essential oil varied between 1.25 and 5 mg mL(-1) and the minimum bactericidal concentrations were superior to 5 mg mL(-1) of oil for most strains. These results may suggest that the root oil of R. segetum possesses compounds with antibacterial and antioxidant capacities, and therefore can be explored as a natural preservative ingredient in food and/or for pharmaceutical preparations.
本工作描述了 Ridolfia segetum 根油的化学成分，并评价了其抗菌和抗氧化性能。Ridolfia segetum 是一种广泛分布于突尼斯的传统药用植物。通过 GC、GC/MS 和 (13)C-NMR 的组合分析，鉴定出该植物精油的主要成分为大根香叶烯醇（47.4%）和肉豆蔻醚（19.2%）。采用 2,2'-二苯基-1-苦基肼自由基清除法评价了精油的抗氧化潜力。富含苯丙素的根油具有良好的抗氧化性能（IC(50) = 38 mg mL(-1)）。采用微量稀释法评价了精油的抗菌活性，结果表明该精油能抑制多种常见的人致病菌以及一些临床和环境分离株。精油的最小抑菌浓度在 1.25 和 5 mg mL(-1)之间，对大多数菌株而言，最小杀菌浓度高于 5 mg mL(-1)的精油。这些结果表明，R. segetum 根油可能含有具有抗菌和抗氧化能力的化合物，因此可以作为天然防腐剂成分用于食品和/或药物制剂。
