Department of Gastroenterology and Hepatology, Tokyo Medical University, 6-7-1 Nishishinjyuku, Shinjyuku-ku, Tokyo 160-0023, Japan.
World J Gastroenterol. 2010 Apr 21;16(15):1890-5. doi: 10.3748/wjg.v16.i15.1890.
To examine the coexistence of metachronous and synchronous cancer in branch duct intraductal papillary mucinous neoplasms of the pancreas (IPMN).
We reviewed the records of 145 patients with branch duct IPMN between January 1991 and April 2008 and assessed the relationship between IPMN and intra- or extra-pancreatic carcinoma and the outcome of IPMN.
The mean observation period was 55.9 +/- 45.3 mo. Among the 145 patients, the frequency of extra-pancreatic cancer was 29.0%. The frequency of gastric cancer, colon cancer, breast cancer, and pancreatic cancer were 25.5%, 15.7%, 13.7%, and 9.8%, respectively. Twenty (13.8%) of the patients died. The cause of death was extra-pancreatic carcinoma in 40%, pancreatic cancer in 25%, IPMN per se in 20%, and benign disease in 15% of the patients.
The prognosis for IPMN depends not on the IPMN per se, but on the presence of intra- or extra-pancreatic cancer.
探讨胰腺分支导管内乳头状黏液性肿瘤（IPMN）中同时性和异时性癌症的共存情况。
我们回顾了 1991 年 1 月至 2008 年 4 月期间 145 例分支导管 IPMN 患者的记录，并评估了 IPMN 与胰内或胰外癌之间的关系以及 IPMN 的转归。
平均观察期为 55.9 +/- 45.3 个月。在 145 例患者中，胰外癌的发生率为 29.0%。胃癌、结肠癌、乳腺癌和胰腺癌的发生率分别为 25.5%、15.7%、13.7%和 9.8%。20 例（13.8%）患者死亡。死亡原因分别为胰外癌 40%、胰腺癌 25%、IPMN 本身 20%和良性疾病 15%。
IPMN 的预后不仅取决于 IPMN 本身，还取决于胰内或胰外癌的存在。
