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髋部骨折住院患者骨质疏松治疗的错失机会。

Missed opportunities for osteoporosis treatment in patients hospitalized for hip fracture.

机构信息

San Francisco VA Medical Center, and Department of Medicine, University of California San Francisco, San Francisco, California, USA.

出版信息

J Am Geriatr Soc. 2010 Apr;58(4):650-7. doi: 10.1111/j.1532-5415.2010.02769.x.

Abstract

OBJECTIVES

Although osteoporosis treatment can dramatically reduce fracture risk, rates of treatment after hip fracture remain low. In-hospital initiation of recommended medications has improved outcomes in heart disease; hospitalization for hip fracture may represent a similar opportunity for improvement. The objective of this study was to examine rates of in-hospital treatment with a combination of calcium and vitamin D (Cal+D) and antiresorptive or bone-forming medications in patients hospitalized for hip fractures

DESIGN

Observational cohort.

SETTING

Three hundred eighteen hospitals in the United States.

PARTICIPANTS

Fifty-one thousand three hundred forty-six patients aged 65 and older hospitalized for osteoporotic hip fracture.

MEASUREMENTS

In-hospital administration of Cal+D and antiresorptive or bone-forming medications.

RESULTS

Three thousand four hundred five patients (6.6%) received Cal+D anytime after a procedure to correct femoral fracture; 3,763 patients (7.3%) received antiresorptive or bone-forming medications. Only 1,023 patients (2.0%) were prescribed ideal therapy, receiving Cal+D and an antiresorptive or bone-forming medication. Treatment rates remained low across virtually all patient-, provider-, and hospital-level characteristics. The strongest predictor of treatment with Cal+D was the receipt of an antiresorptive or bone-forming medication (adjusted odds ratio=5.50, 95% confidence interval=4.84-6.25), but only 27.2% of patients who received these medications also received Cal+D.

CONCLUSION

Rates of in-hospital initiation of osteoporosis treatment for patients with hip fracture are low and may represent an opportunity to improve care.

摘要

目的

尽管骨质疏松症治疗可以显著降低骨折风险,但髋部骨折后的治疗率仍然较低。在心脏病患者中,住院时开始使用推荐药物已改善了治疗效果;髋部骨折住院可能代表了改善治疗的类似机会。本研究的目的是检查因骨质疏松性髋部骨折住院的患者中,联合使用钙和维生素 D(Cal+D)以及抗吸收或成骨药物的住院治疗率。

设计

观察性队列研究。

地点

美国 318 家医院。

参与者

51346 名年龄在 65 岁及以上的因骨质疏松性髋部骨折住院的患者。

测量

住院期间给予 Cal+D 和抗吸收或成骨药物的情况。

结果

3405 名患者(6.6%)在进行纠正股骨骨折的手术后的任何时间接受了 Cal+D;3763 名患者(7.3%)接受了抗吸收或成骨药物治疗。仅有 1023 名患者(2.0%)接受了理想的治疗,即同时接受了 Cal+D 和抗吸收或成骨药物治疗。在几乎所有患者、医生和医院层面的特征中,治疗率仍然很低。接受 Cal+D 的最强预测因素是接受抗吸收或成骨药物治疗(调整后的优势比=5.50,95%置信区间=4.84-6.25),但仅 27.2%接受这些药物治疗的患者也同时接受了 Cal+D。

结论

髋部骨折患者住院时开始骨质疏松症治疗的比率较低,这可能代表改善治疗的机会。

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