一项关于强迫症患者在策略加工和情景记忆方面的性别差异的病例对照研究。

A case-control study of sex differences in strategic processing and episodic memory in obsessive-compulsive disorder.

机构信息

Department of Psychiatry, Obsessive-Compulsive Disorder Clinical and Research Unit, Hospital Universitario de Bellvitge, Barcelona 08907, Spain.

出版信息

Compr Psychiatry. 2010 May-Jun;51(3):303-11. doi: 10.1016/j.comppsych.2009.05.008. Epub 2009 Jul 9.

DOI:10.1016/j.comppsych.2009.05.008

PMID:20399341

Abstract

Although clinical and genetic data for obsessive-compulsive disorder (OCD) support the hypothesis of sexual dimorphism, the neuropsychological findings remain inconclusive. The aim of our study was to determine whether there are differences in cognitive performance between men and women with OCD as compared with healthy controls (HCs). A neuropsychological battery was administered to 50 patients with OCD (31 men and 19 women) and 50 HCs matched by sex, age, and educational level with patients. We evaluated intelligence, attention, episodic memory, and use of organizational strategies during encoding of verbal and nonverbal information. Male patients scored worse than controls did in measures of nonverbal memory tasks, whereas the cognitive performance of women with OCD was consistent with that of their HC counterparts. These results suggest a distinct pattern of cognitive dysfunction specific to the patients' sex.

摘要

虽然强迫症（OCD）的临床和遗传数据支持性别二态性假说，但神经心理学研究结果仍不确定。我们的研究旨在确定强迫症患者（男性 31 例，女性 19 例）与健康对照组（HCs）之间的认知表现是否存在差异。对 50 例强迫症患者（31 名男性和 19 名女性）和 50 名按性别、年龄和教育程度与患者匹配的 HCs 进行了神经心理学测试。我们评估了智力、注意力、情景记忆以及言语和非言语信息编码过程中组织策略的使用。男性患者在非言语记忆任务中的表现差于对照组，而强迫症女性患者的认知表现与 HCs 一致。这些结果表明，特定于患者性别的认知功能障碍存在明显的模式。