University of Alberta, 2935-66 Street, Edmonton, Alberta, Canada.
Hum Exp Toxicol. 2011 Jan;30(1):3-18. doi: 10.1177/0960327110368417. Epub 2010 Apr 16.
There is compelling evidence that various chemical agents are important determinants of myriad health afflictions--several xenobiotics have the potential to disrupt reproductive, developmental, and neurological processes and some agents in common use have carcinogenic, epigenetic, endocrine-disrupting, and immune-altering action. Some toxicants appear to have biological effect at miniscule levels and certain chemical compounds are persistent and bioaccumulative within the human body. Despite escalating public health measures to preclude further exposures, many people throughout the world have already accrued a significant body burden of toxicants, placing them at potential health risk. As a result, increasing discussion is underway about possible interventions to facilitate elimination of persistent toxicants from the human organism in order to obviate health affliction and to potentially ameliorate chronic degenerative illness. An overview of the clinical aspects of detoxification is presented with discussion of established and emerging interventions for the elimination of persistent xenobiotics. Potential therapies to circumvent enterohepatic recirculation and a case report highlighting a clinical outcome associated with detoxification are also presented for consideration.
有确凿的证据表明，各种化学物质是导致许多健康问题的重要决定因素——一些外来化学物质有可能破坏生殖、发育和神经过程，一些常用的物质具有致癌、表观遗传、内分泌干扰和免疫改变作用。一些有毒物质在微小水平似乎具有生物效应，某些化学物质在人体内具有持久性和生物累积性。尽管为了防止进一步暴露而采取了越来越多的公共卫生措施，但世界上许多人已经积累了大量的有毒物质，使他们面临潜在的健康风险。因此，人们越来越多地讨论可能的干预措施，以促进从人体中消除持久性有毒物质，以避免健康问题，并可能改善慢性退行性疾病。本文概述了解毒的临床方面，并讨论了消除持久性外来化学物质的既定和新兴干预措施。还提出了潜在的治疗方法来避免肠肝再循环，并报告了一个突出与解毒相关的临床结果的案例，以供考虑。
