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Opiate receptors for behavioral analgesia resemble those related to the depression of spinal nociceptive neurons.

作者信息

Yaksh T L

出版信息

Science. 1978 Mar 17;199(4334):1231-3. doi: 10.1126/science.204008.

DOI:10.1126/science.204008
PMID:204008
Abstract

With naloxone as antagonist, a dose-ratio analysis of the depression by morphine of nociceptive neurons in the spinal cord reveals that this opiate depression of single unit activity has the same pharmacological properties as observed with morphine analgesia. This suggests that the opiate receptor, mediating the observed cellular depression, and those mediating analgesia are presumably the same.

摘要

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