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有证据表明，脊髓背角胶状质中的阿片受体参与了静脉注射吗啡对无髓初级传入纤维冲动脊髓传导的抑制作用。

Evidence that the opiate receptors of the substantia gelatinosa contribute to the depression, by intravenous morphine, of the spinal transmission of impulses in unmyelinated primary afferents.

作者信息

Johnson S M, Duggan A W

出版信息

Brain Res. 1981 Feb 23;207(1):223-8. doi: 10.1016/0006-8993(81)90698-3.

DOI:10.1016/0006-8993(81)90698-3
PMID:6258733
Abstract

In barbiturate anaesthetized cats, dorsal horn neurones were excited by electrical stimulation of the common tibial nerve. The numbers of action potentials evoked by excitation of C fibres were depressed by analgesic doses of morphine (1-4 mg/kg i.v.). Naloxone, administered electrophoretically in the substantia gelatinosa, fully reversed the inhibitory action of morphine. The results suggest that opiate receptors in the substantia gelatinosa play a role in morphine analgesia.

摘要

在巴比妥类麻醉的猫中，通过电刺激胫总神经可使背角神经元兴奋。C纤维兴奋所诱发的动作电位数量，在给予镇痛剂量的吗啡（静脉注射1 - 4毫克/千克）后会受到抑制。在胶状质中通过电泳法给予纳洛酮，可完全逆转吗啡的抑制作用。结果表明，胶状质中的阿片受体在吗啡镇痛中发挥作用。

相似文献

1
Evidence that the opiate receptors of the substantia gelatinosa contribute to the depression, by intravenous morphine, of the spinal transmission of impulses in unmyelinated primary afferents.有证据表明，脊髓背角胶状质中的阿片受体参与了静脉注射吗啡对无髓初级传入纤维冲动脊髓传导的抑制作用。
Brain Res. 1981 Feb 23;207(1):223-8. doi: 10.1016/0006-8993(81)90698-3.
2
Lamina-specific alteration of C-fibre evoked activity by morphine in the dorsal horn of the rat spinal cord.
Neurosci Lett. 1981 Aug 7;25(1):37-41. doi: 10.1016/0304-3940(81)90097-5.
3
Suppression of transmission of nociceptive impulses by morphine: selective effects of morphine administered in the region of the substantia gelatinosa.吗啡对伤害性冲动传导的抑制作用：在胶状质区域注射吗啡的选择性效应
Br J Pharmacol. 1977 Sep;61(1):65-76.
4
[Morphine analgesia: neurobiologic data].[吗啡镇痛：神经生物学数据]
Ann Anesthesiol Fr. 1978;19(5):343-69.
5
Differing distributions of receptors for morphine and Met5-enkephalinamide in the dorsal horn of the cat.
Brain Res. 1981 Dec 21;229(2):379-87. doi: 10.1016/0006-8993(81)91002-7.
6
Clonidine and the hyper-responsiveness of dorsal horn neurones following morphine withdrawal in the spinal cat.可乐定与脊髓猫吗啡戒断后背角神经元的高反应性
Neuropharmacology. 1987 Oct;26(10):1499-502. doi: 10.1016/0028-3908(87)90169-9.
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Supraspinal inhibition of the excitation of dorsal horn neurones by impulses in unmyelinated primary afferents: lack of effect by strychnine and bicuculline.无髓初级传入纤维冲动对脊髓背角神经元兴奋的脊髓上抑制：士的宁和荷包牡丹碱无作用
Brain Res. 1981 Apr 6;210(1-2):231-41. doi: 10.1016/0006-8993(81)90896-9.
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Morphine and supraspinal inhibition of spinal neurones: evidence that morphine decreases tonic descending inhibition in the anaesthetized cat.吗啡与脊髓神经元的脊髓上抑制：吗啡降低麻醉猫紧张性下行抑制的证据
Br J Pharmacol. 1980 Jul;69(3):461-6. doi: 10.1111/j.1476-5381.1980.tb07035.x.
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Differential effects of morphine and opioid analgesics on A and C fibre-evoked activity in ascending axons of the rat spinal cord.吗啡和阿片类镇痛药对大鼠脊髓升支轴突中A纤维和C纤维诱发活动的不同影响。
Brain Res. 1979 Aug 10;171(3):573-6. doi: 10.1016/0006-8993(79)91065-5.
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Action of capsaicin on dorsal root-evoked synaptic transmission to substantia gelatinosa neurons in adult rat spinal cord slices.
Brain Res. 1999 Jun 5;830(2):268-73. doi: 10.1016/s0006-8993(99)01408-0.

引用本文的文献

1
Opioid-induced long-term potentiation in the spinal cord is a presynaptic event.脊髓中阿片类药物诱导的长期增强是一种突触前事件。
J Neurosci. 2010 Mar 24;30(12):4460-6. doi: 10.1523/JNEUROSCI.5857-09.2010.
2
Excitatory interneurons dominate sensory processing in the spinal substantia gelatinosa of rat.兴奋性中间神经元在大鼠脊髓胶状质的感觉处理中占主导地位。
J Physiol. 2007 May 15;581(Pt 1):241-54. doi: 10.1113/jphysiol.2006.126912. Epub 2007 Mar 1.
3
Morphine administered in the substantia gelatinosa of the spinal trigeminal nucleus caudalis inhibits nociceptive activities in the spinal trigeminal nucleus oralis.
给予三叉神经尾侧亚核胶状质的吗啡可抑制三叉神经脑桥核的伤害性活动。
J Neurosci. 1998 May 15;18(10):3529-36. doi: 10.1523/JNEUROSCI.18-10-03529.1998.
4
Glycine and GABAA receptor-mediated synaptic transmission in rat substantia gelatinosa: inhibition by mu-opioid and GABAB agonists.甘氨酸和GABAA受体介导的大鼠脊髓背角胶状质突触传递：μ-阿片类和GABAB激动剂的抑制作用
J Physiol. 1998 Mar 1;507 ( Pt 2)(Pt 2):473-83. doi: 10.1111/j.1469-7793.1998.473bt.x.
5
Morphine and substance P release in the spinal cord.
Exp Brain Res. 1990;82(1):89-96. doi: 10.1007/BF00230841.
6
Analgesic doses of morphine do not reduce noxious stimulus-evoked release of immunoreactive neurokinins in the dorsal horn of the spinal cat.镇痛剂量的吗啡不会降低脊髓麻醉猫背角中伤害性刺激诱发的免疫反应性神经激肽的释放。
Br J Pharmacol. 1991 Aug;103(4):1871-6. doi: 10.1111/j.1476-5381.1991.tb12344.x.