利妥昔单抗诱发的多形性室性心动过速。
Rituximab-induced polymorphic ventricular tachycardia.
作者信息
Poterucha Joseph T, Westberg Mark, Nerheim Pamela, Lovell James P
机构信息
Department of Internal Medicine & Pediatrics, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA.
出版信息
Tex Heart Inst J. 2010;37(2):218-20.
Abstract
The anti-CD20 monoclonal antibody rituximab is an effective treatment for small lymphocytic lymphoma; however, it has been associated with infusion reactions, including cardiac arrhythmias. Severe cardiac arrhythmia is an adverse reaction that is related to rituximab chemotherapy, and more investigation is warranted into the adverse reactions of rituximab that involve cardiac conduction abnormalities. Herein, we report what we believe to be the 1st case of symptomatic polymorphic ventricular tachycardia to have occurred during an initial infusion of rituximab.
摘要
抗CD20单克隆抗体利妥昔单抗是治疗小淋巴细胞淋巴瘤的有效药物；然而，它与输注反应有关，包括心律失常。严重心律失常是与利妥昔单抗化疗相关的不良反应，因此有必要对利妥昔单抗涉及心脏传导异常的不良反应进行更多研究。在此，我们报告了我们认为是首例在首次输注利妥昔单抗期间发生的症状性多形性室性心动过速病例。
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本文引用的文献
1
Impact of left ventricular epicardial and biventricular pacing on ventricular repolarization in normal-heart individuals and patients with congestive heart failure.左心室心外膜起搏和双心室起搏对正常心脏个体及充血性心力衰竭患者心室复极的影响。
Europace. 2006 Nov;8(11):1002-10. doi: 10.1093/europace/eul110.
2
Delayed reduction in left ventricular function following treatment of non-Hodgkin's lymphoma with chemotherapy and rituximab, unrelated to acute infusion reaction.非霍奇金淋巴瘤经化疗和利妥昔单抗治疗后左心室功能延迟降低，与急性输注反应无关。
Cardiology. 2006;105(3):184-7. doi: 10.1159/000091416. Epub 2006 Feb 14.
3
Impact of atrioventricular node ablation and pacing therapy on clinical course in patients with permanent atrial fibrillation and unstable ventricular tachycardia induced by rapid ventricular response: follow-up study.房室结消融和起搏治疗对永久性心房颤动伴快速心室反应诱发的不稳定室性心动过速患者临床病程的影响：随访研究
Croat Med J. 2005 Dec;46(6):929-35.
4
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5
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J Clin Oncol. 2003 May 1;21(9):1746-51. doi: 10.1200/JCO.2003.09.027.
6
Sudden death after radiofrequency ablation of the atrioventricular node in patients with atrial fibrillation.
J Am Coll Cardiol. 2002 Jul 3;40(1):105-10. doi: 10.1016/s0735-1097(02)01927-7.
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N Engl J Med. 2002 Jan 24;346(4):235-42. doi: 10.1056/NEJMoa011795.
8
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