Liu Hongmei, Cai Cheng, Ding Yanghao, Chen Jianhui, Liu Bosheng, Xia Yuanzhi
College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, China.
ACS Omega. 2020 May 12;5(20):11655-11670. doi: 10.1021/acsomega.0c00951. eCollection 2020 May 26.
An efficient method to access ()-trisubstituted alkenes is reported via cobalt-catalyzed isomerization of 1,1-disubstituted alkenes using a phosphine-amido-oxazoline ligand. The reaction could also convert mono- and 1,2-disubstituted alkenes to ()-internal alkenes with benzylic selectivity. This protocol is atom-economy and operationally simple and uses readily available starting materials with good functional tolerance. This catalytic system could be scaled up to gram scale smoothly with a catalyst loading of 0.1 mol %.
报道了一种通过使用膦-酰胺-恶唑啉配体，钴催化1,1-二取代烯烃异构化来制备（）-三取代烯烃的有效方法。该反应还可以将单取代和1,2-二取代烯烃转化为具有苄基选择性的（）-内烯烃。该方案原子经济性高，操作简单，使用容易获得的起始原料，官能团耐受性好。该催化体系可以顺利地放大到克级规模，催化剂负载量为0.1 mol%。
