Département de Chimie Moléculaire (SERCO), UMR-5250, ICMG FR-2607, Université Joseph Fourier, CNRS, BP-53, 38041 Grenoble cedex 9, France.
Org Biomol Chem. 2010 May 7;8(9):2204-11. doi: 10.1039/c001800g. Epub 2010 Mar 16.
A new strategy for the preparation of unsymmetrical 2,2'-bis(pyrrolyl)alkanes has been developed. It involved the condensation of pyrrole derivatives onto N-benzylhydroxylamines in the presence of HCl. This two-step procedure provided access to a wide variety of 2,2'-dipyrromethanes (3a-m). It has also been extended to the synthesis of tripyrromethanes 4a-d and of N-confused dipyrromethanes 6a-d.
一种新的制备不对称 2,2'-双（吡咯基）烷的策略已经被开发出来。它包括在 HCl 存在下将吡咯衍生物缩合到 N-苄基羟胺上。这两步法提供了多种 2,2'-二吡咯甲烷（3a-m）的合成途径。该方法也已扩展到三吡咯甲烷 4a-d 和 N-稠合二吡咯甲烷 6a-d 的合成。
