具有 N-杂环卡宾配体的金属环戊二烯基金(III)配合物作为拓扑异构酶 I 抑制剂。
Cyclometalated gold(III) complexes with N-heterocyclic carbene ligands as topoisomerase I poisons.
机构信息
Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, China.
出版信息
Chem Commun (Camb). 2010 Jun 14;46(22):3893-5. doi: 10.1039/c001216e. Epub 2010 Apr 19.
DOI:10.1039/c001216e
PMID:20401423
Abstract
A panel of stable Au(R-C--N--C)(N-heterocyclic carbene) complexes displays prominent in vitro anticancer properties; [Au(C--N--C)(IMe)]CF(3)SO(3) (1, IMe = 1,3-dimethylimidazol-2-ylidene) significantly poisons topoisomerase I in vitro and suppresses tumor growth in nude mice model.
摘要
一组稳定的 [Au(R-C--N--C)(N-杂环卡宾)] (+) 配合物表现出显著的体外抗癌特性；[Au(C--N--C)(IMe)]CF(3)SO(3)（1，IMe = 1,3-二甲基咪唑-2-亚基）在体外显著抑制拓扑异构酶 I，并抑制裸鼠模型中的肿瘤生长。
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