Institute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Beethovenstr. 55, 38106 Braunschweig, Germany.
Dalton Trans. 2013 Mar 14;42(10):3269-84. doi: 10.1039/c2dt32617e. Epub 2012 Dec 7.
Metal complexes with N-heterocyclic carbene (NHC) ligands are widely used in chemistry due to their catalytic properties and applied for olefin metathesis among other reactions. The enhanced application of this type of organometallics has over the last few years also triggered a steadily increasing number of studies in the fields of medicinal chemistry, which take advantage of the fascinating chemical properties of these complexes. In fact it has been demonstrated that metal NHC complexes can be used to develop highly efficient metal based drugs with possible applications in the treatment of cancer or infectious diseases. Complexes of silver and gold have been biologically evaluated most frequently but also platinum or other transition metals have demonstrated promising biological properties.
金属配合物与 N-杂环卡宾（NHC）配体由于其催化性能而在化学中得到广泛应用，并应用于烯烃复分解等反应中。近年来，这种类型的有机金属的应用不断增加，也促使药物化学领域的研究数量稳步增加，这些研究利用了这些配合物迷人的化学性质。事实上，已经证明金属 NHC 配合物可用于开发高效的基于金属的药物，这些药物可能应用于癌症或传染病的治疗。银和金的配合物已得到最频繁的生物学评估，但铂或其他过渡金属也表现出有前途的生物学特性。
