阿片肽对氨基酸反应的调节表明了一种新型的神经元通讯形式。
Opiate peptide modulation of amino acid responses suggests novel form of neuronal communication.
作者信息
Barker J L, Neale J H, Smith T G, Macdonald R L
出版信息
Science. 1978 Mar 31;199(4336):1451-3. doi: 10.1126/science.204016.
PMID:204016
Abstract
Mouse spinal neurons grown in tissue culture were used to study the electrophysiological pharmacology of the opiate peptide leucine-enkephalin. Enkephalin depressed glutamate-evoked responses in a noncompetitive manner independent of any other effects on membrane properties. The results demonstrate a neuromodulatory action of opiate peptide functionally distinct from the conventional neurotransmitter class of operation.
摘要
在组织培养中生长的小鼠脊髓神经元被用于研究阿片肽亮氨酸脑啡肽的电生理药理学。脑啡肽以非竞争性方式抑制谷氨酸诱发的反应，且独立于对膜特性的任何其他影响。结果表明阿片肽的神经调节作用在功能上不同于传统神经递质类别的作用方式。
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