Lissoni P, Esposti D, Esposti G, Mauri R, Resentini M, Morabito F, Fumagalli P, Santagostino A, Delitala G, Fraschini F
J Neural Transm. 1986;65(1):63-73. doi: 10.1007/BF01249612.
Recent reports point to a link between the pineal gland and the opioid system. In order to investigate this relationship, two separate studies were performed on humans. Beta-endorphin plasma levels were determined after melatonin administration (0.2 mg/kg b.w. i.m. at 2 p.m.). Melatonin serum values were evaluated after administration of FK 33-824, a met-enkephalin analogue (0.3 mg i.v. infusion at 9 a.m.). A significant decrease of beta-endorphin plasma levels was observed 120 minutes after melatonin injection. Melatonin release was stimulated by FK 33-824, with a peak at 30 minutes. The present results provide evidence of the inhibitory effect of melatonin on beta-endorphin secretion and the stimulatory action of the opioid peptides on the pineal gland. However, further studies will be required to clarify the relationship between the opioid system and the pineal gland.
最近的报告指出松果体与阿片系统之间存在联系。为了研究这种关系，对人类进行了两项独立的研究。在给予褪黑素（下午2点，0.2毫克/千克体重，肌肉注射）后测定β-内啡肽血浆水平。在给予甲硫氨酸脑啡肽类似物FK 33-824（上午9点，静脉输注0.3毫克）后评估褪黑素血清值。褪黑素注射后120分钟观察到β-内啡肽血浆水平显著下降。FK 33-824刺激褪黑素释放，在30分钟时达到峰值。目前的结果提供了褪黑素对β-内啡肽分泌的抑制作用以及阿片肽对松果体的刺激作用的证据。然而，需要进一步的研究来阐明阿片系统与松果体之间的关系。
