Shul'gina G I, Okhotnikov N V, Ryzhov S O, Cherdakova M V
Institute of Higher Nervous Activity and Neurophysiology, Academy of Sciences of the USSR, Moscow.
Neurosci Behav Physiol. 1990 Mar-Apr;20(2):156-66. doi: 10.1007/BF01268135.
After the administration of a morphine-like opiate, DAGO (D), in a dose of 250 micrograms/kg, a decrease was observed in the probability of movements of a rabbit in response to light flashes, the signal for a defensive reflex. The level of the background impulse activity of the neurons gradually decreased in the sensorimotor cortex and in the hippocampus, and did not change in the visual cortex. The decrease and the recovery of the responses of the neurons to the reinforcing stimulus (electrodermal stimulation of the limb) proceeded unidirectionally in all of the areas of the cortex studied, while there were substantial differences in the relationship to the cortical area studied and to the biological significance of the stimulus in the dynamics of the responses to the inhibitory and reinforced light flashes. The identification of the features of the systemic organization of the neurons during training with change in the properties of the reinforcement under the influence of the preparation under study is discussed, as well as the similarity of some features in the mechanisms of the development of internal inhibition in the defensive situation and of the properties of positive reinforcement.
给兔子注射剂量为250微克/千克的吗啡样阿片类药物DAGO（D）后，观察到兔子对闪光（防御反射信号）做出反应的运动概率降低。感觉运动皮层和海马体中神经元的背景冲动活动水平逐渐降低，而视觉皮层中的活动水平没有变化。在所研究的皮层所有区域中，神经元对强化刺激（肢体的皮肤电刺激）的反应的降低和恢复是单向进行的，而在对抑制性和强化性闪光的反应动态中，与所研究的皮层区域以及刺激的生物学意义的关系存在显著差异。文中讨论了在研究制剂影响下强化特性发生变化时训练过程中神经元系统组织特征的识别，以及防御情境中内抑制发展机制和阳性强化特性中一些特征的相似性。
