Department of Surgery, University of Minnesota, 420 Delaware Street SE, Mayo Mail Code 195, Minneapolis, MN 55455, USA.
Hernia. 2010 Aug;14(4):375-81. doi: 10.1007/s10029-010-0659-y. Epub 2010 Apr 18.
To report our experience with abdominal adhesion formation to various synthetic and biologic prosthetic materials in a rat ventral hernia model.
A total of 14 prostheses, nine synthetic, four biologic, and one bioresorbable, were evaluated in the rat. Two synthetic prostheses had bioresorbable coatings and one consisted of synthetic and bioresorbable materials woven together. The model involved the removal from the midline of a 2.5 x 2.5-cm segment of full-thickness ventral abdominal wall with the test prosthetic material sewed into the defect, thus, exposing the viscera directly to one surface of the prosthesis. There were four or more rats in each group. Adhesions were assessed at autopsy 7 days after operation or later. The results were expressed as the percentage area of prosthesis surface involved.
All 14 of the tested prosthetic materials induced adhesions. Vicryl Mesh and the four biologic varieties had lesser overall adhesion coverage than the bare synthetic prostheses. Sepramesh developed the least adhesion coverage (15%). The two synthetic materials with bioresorbable coatings had smaller areas involved compared to bare synthetic prostheses.
All of the tested prostheses attracted adhesions. Biologic prostheses had smaller areas of coverage compared to synthetic prostheses. Barrier surfaces on synthetic meshes were associated with a much lesser extent of adhesion involvement.
报告我们在大鼠腹疝模型中使用各种合成和生物假体材料的腹部粘连形成经验。
共评估了 14 种假体，其中 9 种为合成材料，4 种为生物材料，1 种为可生物吸收材料。两种合成假体具有可生物吸收的涂层，一种由合成和可生物吸收材料编织而成。该模型涉及从中线切除 2.5 x 2.5 厘米的全层腹侧腹壁段，并用测试假体材料缝合到缺陷中，从而使内脏直接暴露于假体的一个表面。每组有 4 只或更多大鼠。在手术后 7 天或更晚进行尸检时评估粘连。结果表示为假体表面受累面积的百分比。
所有 14 种测试的假体材料均引起粘连。Vicryl Mesh 和四种生物品种的总粘连覆盖面积小于裸露的合成假体。Sepramesh 的粘连覆盖面积最小（15%）。两种具有可生物吸收涂层的合成材料与裸露的合成假体相比，受累面积较小。
所有测试的假体都吸引了粘连。生物假体的覆盖面积比合成假体小。合成网片的屏障表面与粘连受累的程度小得多有关。
