大鼠腹腔内植入聚丙烯网片、聚丙烯/聚乙交酯丙交酯网片与聚酯/猪胶原网片后腹膜粘连的对比研究
Comparative study of peritoneal adhesions after intraperitoneal implantation in rats of meshes of polypropylene versus polypropylene/polyglecaprone versus polyester/porcine collagen.
作者信息
Ribeiro Waston Gonçalves, Rodrigues Diego Vinnicyus Santos, Atta Francisco Felipe Moreira, Ramos Izabelle Smith Frazão, Frazão Fabiola Nassar Sousa, Torres Orlando Jorge Martins, Pitombo Marcos Bettini
机构信息
Master, Fellow PhD degree, Postgraduate Program in Health Sciences, Faculty of Medical Sciences, Universidade do Estado do Rio de Janeiro (UERJ), Brazil. Conception and design of the study, technical procedures, analysis and interpretation of data, statistics analysis, manuscript writing.
Resident, General Surgery Residency Program, Hospital Universitário, Universidade Federal do Maranhão (HU-UFMA), Sao Luis-MA, Brazil. Technical procedures, acquisition of data.
出版信息
Acta Cir Bras. 2019 Aug 19;34(6):e201900603. doi: 10.1590/s0102-865020190060000003.
PURPOSE
To Compare the extent and intensity of adhesions formed between the intra-abdominal organs and the intraperitoneal implants of polypropylene mesh versus polypropylene/polyglecaprone versus polyester/porcine collagen used for correction of abdominal wall defect in rats.
METHODS
After the defect in the abdominal wall, thirty Wistar rats were placed in three groups (ten animals each) for intraperitoneal mesh implant: polypropylene group, polypropylene/polyglecaprone group, and polyester/porcine collagen group. The macroscopic evaluation of the extent and intensity of adhesions was performed 21 days after the implant.
RESULTS
The polypropylene group had a higher statistically significant impairment due to visceral adhesions (p value = 0.002) and a higher degree of intense adherence in relation to polypropylene/polyglecaprone and polyester/porcine collagen groups (p value<0.001). The polyester/porcine collagen group showed more intense adhesions than the polypropylene/polyglecaprone group (p value=0.035).
CONCLUSIONS
The intraperitoneal implantation of polypropylene meshes to correct defects of the abdominal wall caused the appearance of extensive and firm adhesions to intra-abdominal structures. The use of polypropylene/polyglecaprone or polyester/porcine collagen tissue-separating meshes reduces the number and degree of adhesions formed.
目的
比较聚丙烯网片、聚丙烯/聚乙交酯丙交酯网片以及聚酯/猪胶原网片用于修复大鼠腹壁缺损时，腹腔内器官与腹腔内植入物之间形成粘连的程度和强度。
方法
造成腹壁缺损后，将30只Wistar大鼠分为三组（每组10只）进行腹腔内网片植入：聚丙烯组、聚丙烯/聚乙交酯丙交酯组和聚酯/猪胶原组。植入后21天对粘连的程度和强度进行宏观评估。
结果
与聚丙烯/聚乙交酯丙交酯组和聚酯/猪胶原组相比，聚丙烯组因内脏粘连导致的统计学显著损伤更高（p值 = 0.002），且粘连程度更严重（p值<0.001）。聚酯/猪胶原组的粘连比聚丙烯/聚乙交酯丙交酯组更严重（p值 = 0.035）。
结论
腹腔内植入聚丙烯网片修复腹壁缺损会导致腹腔内结构出现广泛且牢固的粘连。使用聚丙烯/聚乙交酯丙交酯或聚酯/猪胶原组织隔离网片可减少粘连的数量和程度。
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