Department of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, Massachusetts 01003, USA.
Macromol Biosci. 2010 May 14;10(5):481-7. doi: 10.1002/mabi.200900455.
Random diblock copolymer scaffolds grafted with diamidopyridine (DAP) hydrogen bonding recognition units self-assembled to furnish microspheres when mixed with monoblock copolymers decorated with complementary recognition elements. Through choice of block length, microspheres of various sizes could be produced. The relative length of the two blocks plays a crucial role in determining the formation of aggregates. PEG-b-P(S-co-S(DAP)) diblock copolymer was used to fabricate recognition induced pegylated microspheres, by non-covalent crosslinking with monoblock copolymer functionalized with complementary thymine (Thy) units. These self-assembled microspheres can be efficiently crosslinked via photochemical [2pi(s) + 2pi(s)] cycloaddition with the resultant morphology change into vesicular structures.
随机二嵌段共聚物支架接枝双酰胺吡啶（DAP）氢键识别单元，与带有互补识别元素的单嵌段共聚物混合时自组装成微球。通过选择嵌段长度，可以制备各种大小的微球。两个嵌段的相对长度在确定聚集物的形成中起着关键作用。PEG-b-P（S-co-S（DAP））二嵌段共聚物与用互补胸腺嘧啶（Thy）单元功能化的单嵌段共聚物通过非共价交联来制备识别诱导的聚乙二醇化微球。这些自组装的微球可以通过光化学[2pi(s) + 2pi(s)]环加成有效地交联，其形态变化为囊泡结构。
