Department of Microbiology, Ohio State Biochemistry Program, and Center for RNA Biology, The Ohio State University, Columbus, OH 43210, USA.
Cell. 2010 Apr 16;141(2):227-9. doi: 10.1016/j.cell.2010.03.033.
Sixty-one codons specify 20 amino acids, offering cells many options for encoding a polypeptide sequence. Two new studies (Cannarrozzi et al., 2010; Tuller et al., 2010) now foster the idea that patterns of codon usage can control ribosome speed, fine-tuning translation to increase the efficiency of protein synthesis.
61 个密码子指定 20 种氨基酸,为细胞编码多肽序列提供了多种选择。两项新研究(Cannarrozzi 等人,2010 年;Tuller 等人,2010 年)现在提出了这样一种观点,即密码子使用模式可以控制核糖体的速度,从而微调翻译,提高蛋白质合成的效率。