诱导多能干细胞：范式转变之外的未来。
Induced pluripotent stem cells: what lies beyond the paradigm shift.
机构信息
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198-6805, USA.
出版信息
Exp Biol Med (Maywood). 2010 Feb;235(2):148-58. doi: 10.1258/ebm.2009.009267.
Abstract
The discovery that somatic cells can be reprogrammed to become induced pluripotent stem (iPS) cells has ushered in a new and exciting era in regenerative medicine. Since the seminal discovery of somatic cell reprogramming by Takahashi and Yamanaka in 2006, there has been remarkable progress in the characterization of iPS cells and the protocols used to generate them. The new information generated during the past year alone has vastly expanded our understanding of these cells. Accordingly, this review provides a basic overview of the different strategies used to generate iPS cells and focuses on recent developments in the field of iPS cells. In the final section, we discuss three broad, unanswered questions related to somatic cell reprogramming, which are just starting to be addressed.
摘要
体细胞可以被重编程为诱导多能干细胞（iPS 细胞）的发现开创了再生医学的一个崭新而令人兴奋的时代。自 2006 年 Takahashi 和 Yamanaka 开创性地发现体细胞重编程以来，iPS 细胞的特性和生成它们的方案已经取得了显著的进展。仅在过去一年中产生的新信息就极大地扩展了我们对这些细胞的理解。因此，本综述提供了生成 iPS 细胞的不同策略的基本概述，并重点介绍了 iPS 细胞领域的最新进展。在最后一节中，我们讨论了与体细胞重编程相关的三个广泛的、尚未解决的问题，这些问题才刚刚开始得到解决。
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