Queiroz D M, Mendes E N, Rocha G A, Barbosa A J, Carvalho A S, Cunha-Melo J R
Department of Pathology, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Gut. 1991 May;32(5):464-6. doi: 10.1136/gut.32.5.464.
The histamine concentration was determined by enzymatic isotopic method in biopsy specimens of oxyntic mucosa from 37 children. Nineteen of the 37 had Helicobacter pylori associated gastritis (9 with duodenal ulcer). The histamine concentration in the H pylori negative group was mean (SD) 54.1 (23.1) micrograms/g fresh weight, and that in the H pylori positive group was 26.3 (14.2) micrograms/g (p less than 0.01). There was also a significant difference between H pylori positive patients with duodenal ulcer (19.8 (6.3) micrograms/g) and those without ulcer (31.4 (17.9) micrograms/g) (p less than 0.05). These results suggest that H pylori positive patients, especially those with duodenal ulcer, have reduced 'stored' histamine, perhaps because of increased histamine liberation.
采用酶促同位素法测定了37名儿童胃体黏膜活检标本中的组胺浓度。37名儿童中，19名患有幽门螺杆菌相关性胃炎（9名患有十二指肠溃疡）。幽门螺杆菌阴性组的组胺浓度平均（标准差）为54.1（23.1）微克/克鲜重，幽门螺杆菌阳性组为26.3（14.2）微克/克（p<0.01）。幽门螺杆菌阳性的十二指肠溃疡患者（19.8（6.3）微克/克）与无溃疡患者（31.4（17.9）微克/克）之间也存在显著差异（p<0.05）。这些结果表明，幽门螺杆菌阳性患者，尤其是十二指肠溃疡患者，“储存”的组胺减少，可能是因为组胺释放增加。
