对 p53 激活的新认识。
New insights into p53 activation.
机构信息
Stemline Therapeutics, Inc., Suite 34-L, New York, NY 10128, USA.
出版信息
Cell Res. 2010 Jun;20(6):614-21. doi: 10.1038/cr.2010.53. Epub 2010 Apr 20.
Abstract
The tumor suppressor p53 is a multifunctional, highly regulated, and promoter-specific transcriptional factor that is uniquely sensitive to DNA damage and cellular stress signaling. The mechanisms by which p53 directs a damaged cell down either a cell growth arrest or an apoptotic pathway remain poorly understood. Evidence suggests that the in vivo functions of p53 seem to balance the cell-fate choice with the type and severity of damage that occurs. The concept of antirepression, or inhibition of factors that normally keep p53 at bay, may help explain the physiological mechanisms for p53 activation. These factors also provide novel chemotherapeutic targets for the reactivation of p53 in tumors harboring a wild-type copy of the gene.
摘要
肿瘤抑制因子 p53 是一种多功能、高度调节的、启动子特异性转录因子，对 DNA 损伤和细胞应激信号特别敏感。p53 指导受损细胞选择细胞生长停滞或凋亡途径的机制仍不清楚。有证据表明，p53 的体内功能似乎与发生的损伤类型和严重程度相平衡细胞命运的选择。反抑制的概念，或抑制通常使 p53 处于静止状态的因素，可能有助于解释 p53 激活的生理机制。这些因素也为携带野生型基因的肿瘤中 p53 的重新激活提供了新的化疗靶点。
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