p53的调控模式。
Modes of p53 regulation.
作者信息
Kruse Jan-Philipp, Gu Wei
机构信息
Institute for Cancer Genetics, College of Physicians and Surgeons, Columbia University, 1130 St. Nicholas Avenue, New York, NY 10032, USA.
出版信息
Cell. 2009 May 15;137(4):609-22. doi: 10.1016/j.cell.2009.04.050.
Abstract
The traditional view of p53 activation includes three steps-p53 stabilization, DNA binding, and transcriptional activation. However, recent studies indicate that each step of p53 activation is more complex than originally anticipated. Moreover, both genetic studies in mice and in vitro studies with purified components suggest that the classical model may not be sufficient to explain all aspects of p53 activation in vivo. To reconcile these differences, we propose that antirepression, the release of p53 from repression by factors such as Mdm2 and MdmX, is a key step in the physiological activation of p53.
摘要
对p53激活的传统观点包括三个步骤——p53稳定、DNA结合和转录激活。然而，最近的研究表明，p53激活的每个步骤都比最初预期的更为复杂。此外，小鼠中的遗传学研究以及使用纯化成分进行的体外研究均表明，经典模型可能不足以解释p53在体内激活的所有方面。为了调和这些差异，我们提出抗抑制作用，即p53从诸如Mdm2和MdmX等因子的抑制作用中释放出来，是p53生理激活的关键步骤。
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