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自体角膜缘结膜移植联合干细胞治疗翼状胬肉的疗效

Efficacy of Limbal-conjunctival Autograft Surgery with Stem Cells in Pterygium Treatment.

作者信息

Abdalla Walid M

机构信息

Department of Ophthalmology, Magrabi Eye and Ear Center, Muscat, Sultanate of Oman.

出版信息

Middle East Afr J Ophthalmol. 2009 Oct;16(4):260-2. doi: 10.4103/0974-9233.58417.

DOI:10.4103/0974-9233.58417
PMID:20404994
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2855668/
Abstract

PURPOSE

To determine the efficacy of limbal-conjunctival autograft surgery with stem cells in the management of primary and recurrent pterygium and determine the best corrected visual acuity after surgery.

MATERIALS AND METHODS

Surgical excision of pterygium and limbal-conjunctival transplantation with stem cells was of 40 eyes (of 31 patients) with pterygium. Thirty one cases were primary and nine cases were recurrent pterygia. Graft margins were secured to the recipient site while stem cells aspect was sutured to the limbus.

RESULTS

After one year of follow-up, 37 of 40 (92.5%) eyes were free of recurrence. One of the three recurrent cases was aggressive (recurrence occurred two months after surgery) and the other two showed 2 mm corneal extension at 12 months follow-up. In 24 patients, out of 40 (60%), best corrected visual acuity improved more than two lines.

CONCLUSION

Limbal-conjunctival autograft surgery, including stem cells, appears to be an effective surgical technique in preventing pterygium recurrence and it can also help in improving the best corrected visual acuity.

摘要

目的

确定带干细胞的角膜缘-结膜自体移植手术治疗原发性和复发性翼状胬肉的疗效,并确定术后最佳矫正视力。

材料与方法

对40只眼(31例患者)的翼状胬肉进行手术切除并带干细胞的角膜缘-结膜移植。31例为原发性翼状胬肉,9例为复发性翼状胬肉。将移植片边缘固定于受体部位,同时将干细胞面缝合于角膜缘。

结果

随访一年后,40只眼中有37只(92.5%)无复发。3例复发病例中有1例为侵袭性(术后2个月复发),另外2例在随访12个月时角膜扩展2mm。40例患者中有24例(60%)最佳矫正视力提高超过两行。

结论

带干细胞的角膜缘-结膜自体移植手术似乎是预防翼状胬肉复发的一种有效手术技术,并且有助于提高最佳矫正视力。

相似文献

1
Efficacy of Limbal-conjunctival Autograft Surgery with Stem Cells in Pterygium Treatment.自体角膜缘结膜移植联合干细胞治疗翼状胬肉的疗效
Middle East Afr J Ophthalmol. 2009 Oct;16(4):260-2. doi: 10.4103/0974-9233.58417.
2
Conjunctival autograft for pterygium.翼状胬肉的结膜自体移植术。
Cochrane Database Syst Rev. 2016 Feb 11;2(2):CD011349. doi: 10.1002/14651858.CD011349.pub2.
3
Randomized trial of pterygium surgery with mitomycin C application using conjunctival autograft versus conjunctival-limbal autograft.随机对照试验研究丝裂霉素 C 应用于翼状胬肉手术中,采用结膜自体移植与结膜-角膜缘自体移植的比较。
Ophthalmology. 2012 Feb;119(2):227-32. doi: 10.1016/j.ophtha.2011.08.002. Epub 2011 Dec 6.
4
Limbal-conjunctival vs conjunctival autograft transplant for recurrent pterygia: a prospective randomized controlled trial.角膜缘-结膜与结膜自体移植治疗复发性翼状胬肉的前瞻性随机对照试验。
JAMA Ophthalmol. 2013 Jan;131(1):11-6. doi: 10.1001/archophthalmol.2012.2599.
5
Treatment of primary pterygium: Role of limbal stem cells and conjunctival autograft transplantation.原发性翼状胬肉的治疗:角膜缘干细胞和结膜自体移植的作用
Oman J Ophthalmol. 2009 Jan;2(1):23-6. doi: 10.4103/0974-620X.48418.
6
Limbal versus conjunctival autograft transplantation for advanced and recurrent pterygium.角膜缘自体移植与结膜自体移植治疗晚期复发性翼状胬肉
Ophthalmology. 2002 Sep;109(9):1752-5. doi: 10.1016/s0161-6420(02)01160-0.
7
A comparative study of recurrent pterygium surgery: limbal conjunctival autograft transplantation versus mitomycin C with conjunctival flap.复发性翼状胬肉手术的比较研究:角膜缘结膜自体移植术与丝裂霉素C联合结膜瓣手术的对比
Ophthalmology. 1999 Apr;106(4):817-21. doi: 10.1016/S0161-6420(99)90172-0.
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Options and adjuvants in surgery for pterygium: a report by the American Academy of Ophthalmology.翼状胬肉手术的选择和辅助治疗:美国眼科学会报告。
Ophthalmology. 2013 Jan;120(1):201-8. doi: 10.1016/j.ophtha.2012.06.066. Epub 2012 Oct 11.
9
Treatment of primary pterygium: role of limbal stem cells and conjunctival autograft transplantation.原发性翼状胬肉的治疗:角膜缘干细胞和结膜自体移植的作用
Eur J Ophthalmol. 2009 Sep-Oct;19(5):729-32. doi: 10.1177/112067210901900507.
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Limbal conjunctival mini-autografting for preventing recurrence after pterygium surgery.角膜缘结膜微小自体移植术预防翼状胬肉术后复发
Eur J Ophthalmol. 2006 Mar-Apr;16(2):209-13. doi: 10.1177/112067210601600203.

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Indian J Ophthalmol. 2023 Dec 1;71(12):3646-3651. doi: 10.4103/IJO.IJO_16_23. Epub 2023 Nov 20.
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Sliding limbus-conjunctival flaps for minimizing the pterygium recurrence: a prospective tertiary care institute study.滑动角膜缘-结膜瓣术预防翼状胬肉复发:一项前瞻性三级保健机构研究。
Rom J Ophthalmol. 2023 Jul-Sep;67(3):244-249. doi: 10.22336/rjo.2023.41.
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Safety profile and complications of autologous limbal conjunctival transplantation for primary pterygium.原发性翼状胬肉自体角膜缘结膜移植术的安全性及并发症
Saudi J Ophthalmol. 2014 Oct;28(4):262-7. doi: 10.1016/j.sjopt.2014.03.006. Epub 2014 Mar 21.

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Limbal conjunctival mini-autografting for preventing recurrence after pterygium surgery.角膜缘结膜微小自体移植术预防翼状胬肉术后复发
Eur J Ophthalmol. 2006 Mar-Apr;16(2):209-13. doi: 10.1177/112067210601600203.
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