Soliman Mahdy Mohamed A E, Bhatia Jagdish
The Ophthalmic Department, Rustaq Hospital, Rustaq - Sultanate of Oman.
Eur J Ophthalmol. 2009 Sep-Oct;19(5):729-32. doi: 10.1177/112067210901900507.
The limbus and its stem cells are important in the pathogenesis of pterygium. In this study, the usefulness of limbal stem cells and conjunctival autograft transplantation for the treatment of primary pterygium is assessed.
In this prospective noncomparative cohort study, 42 eyes of 42 patients with grade I-III primary pterygium underwent pterygium excision followed by superotemporal limbal stem cells and conjunctival autograft transplantation. Pterygium recurrences and complications within a mean follow-up period of 18.26 months (range, 10-28 months) were assessed.
There were no recurrences of pterygium growth except in 2 cases (4.75%). In addition, no significant complications were noted. No further surgical interventions were needed in any case except for reoperation in the 2 recurrent cases.
Although limbal stem cells and conjunctival autograft transplantation is a time-consuming procedure, it is a safe and effective technique for the treatment of different grades of pterygium. It is useful in prevention of pterygium recurrence, which is a major problem in pterygium surgery.
角膜缘及其干细胞在翼状胬肉的发病机制中起重要作用。本研究评估角膜缘干细胞联合结膜自体移植治疗原发性翼状胬肉的有效性。
在这项前瞻性非对照队列研究中，42例患有I-III级原发性翼状胬肉的患者的42只眼接受了翼状胬肉切除，随后进行了颞上角膜缘干细胞和结膜自体移植。评估了平均随访期18.26个月（范围10-28个月）内的翼状胬肉复发情况和并发症。
除2例（4.75%）外，无翼状胬肉复发。此外，未观察到明显并发症。除2例复发病例再次手术外，任何病例均无需进一步手术干预。
尽管角膜缘干细胞联合结膜自体移植是一个耗时的过程，但它是治疗不同等级翼状胬肉的一种安全有效的技术。它有助于预防翼状胬肉复发，这是翼状胬肉手术中的一个主要问题。
