Franceschi S, Levi F, Negri E, Fassina A, La Vecchia C
Epidemiology Unit, Aviano Cancer Center, Italy.
Int J Cancer. 1991 May 30;48(3):395-8. doi: 10.1002/ijc.2910480315.
The relationship between frequencies of consumption of selected indicator foods and the risk of thyroid cancer was investigated in a pooled analysis of 4 case-control studies conducted in 3 areas of northern Italy and the Swiss Canton of Vaud, on a total of 385 histologically confirmed cases of thyroid cancer and 798 controls in hospital for acute, non-neoplastic, non-hormone-related diseases. Cases tended to consume significantly more frequently a number of starchy foods: the odds ratio (OR) for the highest vs. lowest tertile was 1.8 for pasta or rice, 2.1 for bread, 1.6 for pastry and 2.0 for potatoes. ORs also tended to be above unity for several types of meat and significantly so for chicken and poultry, cooked ham, salami and sausages. Raw ham and fish were significantly protective (OR = 0.7 in the highest tertile for both). Significant direct associations were observed with cheese (OR = 1.4 for the highest tertile), butter (OR = 2.1) and oils other than olive (OR = 1.6). The risk estimates were below unity for most types of vegetables and fruits, and the inverse trends were significantly for carrots (OR = 0.6 for the highest tertile), green salad (OR = 0.6) and citrus fruits (OR = 0.7). No association was observed with alcohol intake. These results were consistent and reproducible across various study centers.
在对意大利北部3个地区和瑞士沃州开展的4项病例对照研究进行的汇总分析中，研究了特定指示性食物的食用频率与甲状腺癌风险之间的关系。该分析共纳入385例经组织学确诊的甲状腺癌病例以及798例因急性、非肿瘤性、非激素相关疾病住院的对照。病例食用多种淀粉类食物的频率往往显著更高：面食或米饭最高三分位数与最低三分位数相比的比值比（OR）为1.8，面包为2.1，糕点为1.6，土豆为2.0。几种肉类的OR值也往往高于1，鸡肉和家禽、熟火腿、意大利腊肠和香肠的OR值显著高于1。生火腿和鱼类具有显著的保护作用（两者最高三分位数的OR均为0.7）。与奶酪（最高三分位数的OR = 1.4）、黄油（OR = 2.1）和非橄榄油（OR = 1.6）之间观察到显著的直接关联。大多数蔬菜和水果的风险估计值低于1，胡萝卜（最高三分位数的OR = 0.6）、蔬菜沙拉（OR = 0.6）和柑橘类水果（OR = 0.7）的反向趋势显著。未观察到与饮酒之间的关联。这些结果在各个研究中心是一致且可重复的。
