Lüke W, Fendrich C, Schreiner D, Sprenger R, Rietschel J, Hunsmann G
Department of Virology and Immunology, German Primate Center, Göttingen, FRG.
Intervirology. 1991;32(3):198-203. doi: 10.1159/000150200.
The structural variability of the external glycoproteins of primate immunodeficiency viruses, has, so far, been investigated exclusively by sequence comparison of the respective proviral genomes. We have examined the structural relationship amount the external glycoproteins from three specific human immunodeficiency viruses (HIF-1, HIV-2), three specific simian immunodeficiency viruses from macaques (SIVmac) and three specific SIV from African green monkeys (SIVagm) by peptide mapping. Differences among glycoproteins were most pronounced between HIV-1 and SIVmac, as well as HIV-2. Two specific glycoproteins from independent SIVagm isolates were closely related to HIV-1, whereas the glycoprotein from a third SIVagm isolate was more similar to those of SIVmac and HIV-2. Our analysis reflects the classification of primate immunodeficiency viruses into three groups, the HIV-2 and SIVmac viruses, the green monkey isolates and HIV-1.
迄今为止，灵长类免疫缺陷病毒外膜糖蛋白的结构变异性仅通过对相应前病毒基因组进行序列比较来研究。我们通过肽图谱分析，研究了三种特定的人类免疫缺陷病毒（HIV-1、HIV-2）、三种特定的猕猴猿猴免疫缺陷病毒（SIVmac）和三种特定的非洲绿猴SIV（SIVagm）的外膜糖蛋白之间的结构关系。糖蛋白之间的差异在HIV-1与SIVmac以及HIV-2之间最为明显。来自独立SIVagm分离株的两种特定糖蛋白与HIV-1密切相关，而来自第三个SIVagm分离株的糖蛋白则与SIVmac和HIV-2的糖蛋白更为相似。我们的分析反映了灵长类免疫缺陷病毒可分为三组：HIV-2和SIVmac病毒、绿猴分离株以及HIV-1。
