Jurkiewicz E, Villas-Boas M, Silva J L, Weber G, Hunsmann G, Clegg R M
Abteilung Virologie und Immunologie, Deutsches Primatenzentrum GmbH, Gôttigen, Germany.
Proc Natl Acad Sci U S A. 1995 Jul 18;92(15):6935-7. doi: 10.1073/pnas.92.15.6935.
The inactivation of the simian immunodeficiency viruses SIVmac251 and SIVagm by pressures of 150 and 250 MPa was determined. The extent of inactivation depended on the time that the virus was subjected to compression as well as the level of the pressure and at 150 Mpa reached 5 log10 dilution units after approximately 10 hr. The inactivations, which were uniformly carried out at room temperature, were independent of the concentration of the virus. Possible applications of pressure inactivation for molecular biological and clinical use are discussed.
测定了150兆帕和250兆帕压力对猿猴免疫缺陷病毒SIVmac251和SIVagm的灭活情况。灭活程度取决于病毒受压的时间以及压力水平，在150兆帕时，大约10小时后灭活程度达到5个对数10稀释单位。灭活过程均在室温下进行，且与病毒浓度无关。文中还讨论了压力灭活在分子生物学和临床应用方面的可能用途。
