Department of Human Kinesiology, Capital Institute of Physical Education, Beijing, China.
Physiol Res. 2010;59(5):633-644. doi: 10.33549/physiolres.931928. Epub 2010 Apr 20.
Exercise training-induced cardiac hypertrophy occurs following a program of aerobic endurance exercise training and it is considered as a physiologically beneficial adaptation. To investigate the underlying biology of physiological hypertrophy, we rely on robust experimental models of exercise training in laboratory animals that mimic the training response in humans. A number of experimental strategies have been established, such as treadmill and voluntary wheel running and swim training models that all associate with cardiac growth. These approaches have been applied to numerous animal models with various backgrounds. However, important differences exist between these experimental approaches, which may affect the interpretation of the results. Here, we review the various approaches that have been used to experimentally study exercise training-induced cardiac hypertrophy; including the advantages and disadvantages of the various models.
运动训练引起的心脏肥大发生在有氧耐力运动训练之后，被认为是一种生理性有益的适应。为了研究生理性肥大的潜在生物学机制，我们依赖于实验室动物中强有力的运动训练实验模型，这些模型模拟了人类的训练反应。已经建立了许多实验策略，例如跑步机和自愿轮跑以及游泳训练模型，这些都与心脏生长有关。这些方法已应用于具有各种背景的许多动物模型。然而，这些实验方法之间存在重要差异，这可能会影响结果的解释。在这里，我们回顾了用于实验研究运动训练诱导的心脏肥大的各种方法；包括各种模型的优缺点。
