Department of Otolaryngology-Head and Neck Surgery, Soonchunhyang University College of Medicine , Bucheon, Korea.
Thyroid. 2010 May;20(5):513-7. doi: 10.1089/thy.2009.0397.
This prospective study investigated the efficacy of injection laryn-goplasty in the management of postthyroidectomy vocal cord paralysis (VCP).
From March 2005 to December 2008, 174 consecutive injection laryngoplasties were performed in patients with unilateral glottic insufficiency. This included 34 patients with post-thyroidectomy VCP: 15 with temporary VCP and 19 with permanent VCP. Percutaneous injection was performed under local anesthesia into the vocalis muscle, using disposable 25G-long needles through the cricothyroid membrane or directly through the thyroid cartilage. Patients completed the acoustic, aerodynamic, perceptual, stroboscopic, and voice handicap index evaluations before and at 3 and 6 months after the injection.
All injection laryngoplasty could be performed under local anesthesia without morbidity. Acoustic and perceptual parameters (overall grade of hoarseness, roughness, breathiness, asthenia, and strain), maximum phonation time, jitter, and shimmer, voice handicap index, and grades of mucosal waves and glottic closure were significantly improved after the injection and they remained stable over 6 months in both the temporary VCP and permanent groups (p < 0.05).
Based on these preliminary results, injection laryngoplasty improved the voice, and voice-related quality of life in patients with post-thyroidectomy VCP. It is a simple, safe, and useful method for rehabilitating post-thyroidectomy VCP patients.
本前瞻性研究调查了注射性喉成形术治疗甲状腺切除术后声带麻痹(VCP)的疗效。
从 2005 年 3 月至 2008 年 12 月,174 例单侧声带不全患者连续进行了注射性喉成形术。其中包括 34 例甲状腺切除术后 VCP 患者:15 例为暂时性 VCP,19 例为永久性 VCP。在局部麻醉下,使用一次性 25G 长针经环甲膜或直接经甲状软骨将药物注入声带肌内。患者在注射前、注射后 3 个月和 6 个月时完成声学、空气动力学、感知、频闪和嗓音障碍指数评估。
所有注射性喉成形术均能在局部麻醉下进行,无并发症。声学和感知参数(总嘶哑程度、粗糙度、呼吸音、乏力和紧张度)、最大发音时间、抖动和闪烁、嗓音障碍指数以及黏膜波和声带闭合程度在注射后均显著改善,并且在暂时性 VCP 和永久性 VCP 组中,6 个月内均保持稳定(p < 0.05)。
根据这些初步结果,注射性喉成形术改善了甲状腺切除术后 VCP 患者的嗓音和嗓音相关生活质量。它是一种简单、安全、有效的治疗甲状腺切除术后 VCP 患者的方法。