通过基于社区的建模来开发人类疾病的预测分子图谱。
Developing predictive molecular maps of human disease through community-based modeling.
机构信息
Sage Bionetworks, Seattle, Washington, USA.
出版信息
Nat Genet. 2012 Jan 27;44(2):127-30. doi: 10.1038/ng.1089.
Abstract
The inability to identify the molecular causes of disease has led to a disappointing rate of development of new medicines. By combining the power of community-based modeling with broad access to large datasets on a platform that promotes reproducible analyses, we can work toward more predictive molecular maps that can deliver better therapeutics.
摘要
无法确定疾病的分子原因导致新药的开发率令人失望。通过将基于社区的建模的力量与广泛访问促进可重复分析的平台上的大型数据集相结合，我们可以努力构建更具预测性的分子图谱，从而提供更好的治疗方法。
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本文引用的文献
1
The National Center for Biomedical Ontology.国家生物医学本体研究中心。
J Am Med Inform Assoc. 2012 Mar-Apr;19(2):190-5. doi: 10.1136/amiajnl-2011-000523. Epub 2011 Nov 10.
2
Towards a data sharing Code of Conduct for international genomic research.迈向国际基因组研究数据共享行为准则。
Genome Med. 2011 Jul 14;3(7):46. doi: 10.1186/gm262.
3
Systematic documentation and analysis of human genetic variation in hemoglobinopathies using the microattribution approach.采用微量归因方法对血红蛋白病的人类遗传变异进行系统的文献记载和分析。
Nat Genet. 2011 Mar 20;43(4):295-301. doi: 10.1038/ng.785.
4
Dealing with data. Challenges and opportunities. Introduction.数据处理。挑战与机遇。引言。
Science. 2011 Feb 11;331(6018):692-3. doi: 10.1126/science.331.6018.692.
5
Electronic consent channels: preserving patient privacy without handcuffing researchers.电子同意渠道：在不束缚研究人员的情况下保护患者隐私。
Sci Transl Med. 2011 Feb 9;3(69):69cm4. doi: 10.1126/scitranslmed.3002037.
6
Sharing research data to improve public health.共享研究数据以改善公众健康。
Lancet. 2011 Feb 12;377(9765):537-9. doi: 10.1016/S0140-6736(10)62234-9. Epub 2011 Jan 7.
7
ISA software suite: supporting standards-compliant experimental annotation and enabling curation at the community level.ISA 软件套件：支持符合标准的实验注释，并能够在社区层面进行管理。
Bioinformatics. 2010 Sep 15;26(18):2354-6. doi: 10.1093/bioinformatics/btq415. Epub 2010 Aug 2.
8
Something in common.
Sci Transl Med. 2010 Jul 14;2(40):40ed6. doi: 10.1126/scitranslmed.3001280.
9
The need for precompetitive integrative bionetwork disease model building.需要建立竞争前整合生物网络疾病模型。
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