发热的旅行归来者因扑疟喹啉毒性导致全血细胞减少症。
Pancytopenia due to proguanil toxicity in a returning traveller with fever.
机构信息
Department of Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands.
出版信息
Eur J Clin Pharmacol. 2010 Aug;66(8):811-2. doi: 10.1007/s00228-010-0824-3. Epub 2010 Apr 21.
Abstract
A patient known to have renal insufficiency was admitted to the hospital with fever and pancytopenia after returning from a trip to Mali. Pancytopenia was not caused by a tropical infection but was a side effect of atovaquone/proguanil used as malaria chemoprophylaxis. High and prolonged detectable proguanil serum levels can result in bone marrow suppression in patients with renal insufficiency. This should be taken into account in a returning traveller with fever and pancytopenia.
摘要
一位已知肾功能不全的患者，从马里旅行回来后出现发热和全血细胞减少，收入院治疗。全血细胞减少不是热带感染引起的，而是阿托伐醌/磺胺多辛作为疟疾化学预防用药的副作用。肾功能不全患者，高浓度且长时间可检测到的磺胺多辛血清水平可导致骨髓抑制。对于发热和全血细胞减少的旅行者，应考虑到这一点。
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