肾衰竭患者使用抗疟药的风险。
The risk of antimalarials in patients with renal failure.
作者信息
Thorogood N, Atwal S, Mills W, Jenner M, Lewis D A, Cavenagh J D, Agrawal S G
机构信息
Princess Alexandra Hospital, Harlow, Essex, UK.
出版信息
Postgrad Med J. 2007 Dec;83(986):e8. doi: 10.1136/pgmj.2007.063735.
Abstract
We present here a patient with end stage renal failure who received two weeks antimalarial prophylaxis at full dose leading to life threatening toxicity with severe acute megaloblastic anaemia, symptomatic pancytopenia and exfoliative dermatitis. Prompt recognition and treatment can rapidly reverse these fatal effects but more importantly, education of patients before travel is imperative in preventing such events.
摘要
我们在此报告一名终末期肾衰竭患者，其接受了为期两周的全剂量抗疟疾预防治疗，导致危及生命的毒性反应，出现严重急性巨幼细胞贫血、症状性全血细胞减少和剥脱性皮炎。及时识别和治疗可迅速逆转这些致命影响，但更重要的是，出行前对患者进行教育对于预防此类事件至关重要。
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