Department of Radiology, University of Palermo, Via Del Vespro 129, 90127 Palermo, Italy.
Eur Radiol. 2010 Sep;20(9):2248-56. doi: 10.1007/s00330-010-1775-x. Epub 2010 Apr 21.
To correlate contrast-enhanced ultrasound (CEUS) findings of hepatic focal nodular hyperplasia (FNH) with lesion size, depth and liver echogenicity and to compare CEUS with baseline US.
Two radiologists evaluated baseline US and CEUS examinations of 92 FNHs (mean size: 3.1 +/- 1.7 cm) in 71 patients (59 women and 12 men) to detect the "spoke-wheel" sign, central scar and feeding vessel. The FNHs were grouped and analysed by dimension, depth and liver echogenicity.
At least one sign could be detected at CEUS in 27 out of 36 (75%) FNHs larger than 3 cm and in 17 out of 56 (30%) FNH measuring 3 cm or less (p < 0.0001). No statistically significant differences were noted between lesion depth or liver echogenicity and detection rate of these signs at CEUS (p > 0.05) as well as between CEUS or baseline US/CD with regard to lesion size, depth or liver echogenicity (p > 0.05).
The detection rate of the central scar and spoke-wheel sign in FNH at CEUS is strongly dependent on lesion size and CEUS can confidently diagnose most FNHs larger than 3 cm.
将肝脏局灶性结节性增生（FNH）的增强超声（CEUS）表现与病变大小、深度和肝脏回声强度相关联，并将 CEUS 与基线超声进行比较。
两名放射科医生评估了 71 名患者（59 名女性和 12 名男性）的 92 个 FNH 的基线超声和 CEUS 检查，以检测“辐轮”征、中央瘢痕和供血血管。根据尺寸、深度和肝脏回声强度对 FNH 进行分组和分析。
在 36 个大于 3cm 的 FNH 中有 27 个（75%）和 56 个 3cm 或以下的 FNH 中有 17 个（30%）至少在 CEUS 上可以检测到至少一个征象（p<0.0001）。CEUS 上这些征象的检测率与病变深度或肝脏回声强度之间没有统计学显著差异（p>0.05），CEUS 或基线超声/彩色多普勒与病变大小、深度或肝脏回声强度之间也没有统计学显著差异（p>0.05）。
CEUS 对 FNH 中央瘢痕和辐轮征的检测率强烈依赖于病变大小，CEUS 可以自信地诊断大多数大于 3cm 的 FNH。
