Gugleta K, Kochkorov A, Katamay R, Husner A, Welge-Lüssen A, Flammer J, Orgül S
Ophthalmology Department, University Hospital Basel, Basel, Switzerland.
Klin Monbl Augenheilkd. 2010 Apr;227(4):277-9. doi: 10.1055/s-0029-1245198. Epub 2010 Apr 20.
The aim of this study was to assess the olfactory function of primary open-angle glaucoma patients.
We analyzed odour threshold, identification, and discrimination in 30 primary open-angle glaucoma patients and 30 age- and gender-matched healthy control subjects. The "Sniffin' Sticks" test battery was applied sequentially on both sides, scores of two nostrils were averaged and means were compared with Mann-Whitney U-test between the groups.
Scores for odour threshold were 5.9 +/- 2.2 and 7.4 +/- 2.1 in glaucoma and control group, respectively (p = 0.01), for odour discrimination 10.5 +/- 2.0 and 10.8 +/- 1.6 (p = 0.65), and for odour identification 11.8 +/- 2.1 and 10.6 +/- 1.6 (p = 0.008). Comparing within glaucoma group between those with (n = 18) and without history (n = 12) of cold hands and feet, the former had significantly better odour threshold scores, 6.6 +/- 1.5, than the latter, 4.8 +/- 2.6 (p = 0.036); no difference in other two olfactory modalities were detected.
Changes of olfactory function have been described in neurodegenerations such as Alzheimer and Parkinson diseases. Complex alterations of olfactory performance seem to be present in POAG patients as well.
本研究旨在评估原发性开角型青光眼患者的嗅觉功能。
我们分析了30例原发性开角型青光眼患者以及30例年龄和性别匹配的健康对照者的气味阈值、识别能力和辨别能力。依次对双侧应用“嗅觉棒”测试组合，将两个鼻孔的得分进行平均，并通过曼-惠特尼U检验比较两组之间的平均值。
青光眼组和对照组的气味阈值得分分别为5.9±2.2和7.4±2.1（p = 0.01），气味辨别得分分别为10.5±2.0和10.8±1.6（p = 0.65），气味识别得分分别为11.8±2.1和10.6±1.6（p = 0.008）。在青光眼组中，比较有（n = 18）和无（n = 12）手脚冰凉病史的患者，前者的气味阈值得分（6.6±1.5）显著优于后者（4.8±2.6）（p = 0.036）；在其他两种嗅觉模式中未检测到差异。
在诸如阿尔茨海默病和帕金森病等神经退行性疾病中已描述了嗅觉功能的变化。原发性开角型青光眼患者似乎也存在嗅觉表现的复杂改变。
