Iannucci Valeria, Bruscolini Alice, Iannella Giannicola, Visioli Giacomo, Alisi Ludovico, Salducci Mauro, Greco Antonio, Lambiase Alessandro
Department of Sense Organs, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy.
Biomedicines. 2024 May 2;12(5):1002. doi: 10.3390/biomedicines12051002.
Olfactory dysfunction is a well-known phenomenon in neurological diseases with anosmia and hyposmia serving as clinical or preclinical indicators of Alzheimer's disease, Parkinson's disease, and other neurodegenerative disorders. Since glaucoma is a neurodegenerative disease of the visual system, it may also entail alterations in olfactory function, warranting investigation into potential sensory interconnections.
A review of the current literature of the last 15 years (from 1 April 2008 to 1 April 2023) was conducted by two different authors searching for topics related to olfaction and glaucoma.
three papers met the selection criteria. According to these findings, patients with POAG appear to have worse olfaction than healthy subjects. Furthermore, certain predisposing conditions to glaucoma, such as pseudoexfoliation syndrome and primary vascular dysregulation, could possibly induce olfactory changes that can be measured with the Sniffin Stick test.
the scientific literature on this topic is very limited, and the pathogenesis of olfactory changes in glaucoma is not clear. However, if the results of these studies are confirmed by further research, olfactory testing may be a non-invasive tool to assist clinicians in the early diagnosis of glaucoma.
嗅觉功能障碍在神经疾病中是一种众所周知的现象，嗅觉丧失和嗅觉减退是阿尔茨海默病、帕金森病及其他神经退行性疾病的临床或临床前指标。由于青光眼是视觉系统的一种神经退行性疾病，它也可能导致嗅觉功能改变，因此有必要对潜在的感觉相互联系进行研究。
由两位不同的作者对过去15年（从2008年4月1日至2023年4月1日）的当前文献进行综述，搜索与嗅觉和青光眼相关的主题。
三篇论文符合入选标准。根据这些研究结果，原发性开角型青光眼患者的嗅觉似乎比健康受试者更差。此外，某些青光眼的易感因素，如假性剥脱综合征和原发性血管调节异常，可能会引起嗅觉变化，这种变化可用嗅觉棒测试来测量。
关于这个主题的科学文献非常有限，青光眼嗅觉变化的发病机制尚不清楚。然而，如果这些研究结果得到进一步研究的证实，嗅觉测试可能成为协助临床医生早期诊断青光眼的一种非侵入性工具。
