遗传因素对体感诱发电位的 MEG 记录有影响。

Genetic influence demonstrated for MEG-recorded somatosensory evoked responses.

机构信息

Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands.

出版信息

Psychophysiology. 2010 Nov;47(6):1040-6. doi: 10.1111/j.1469-8986.2010.01012.x.

DOI:10.1111/j.1469-8986.2010.01012.x

PMID:20409017

Abstract

We tested for a genetic influence on magnetoencephalogram (MEG)-recorded somatosensory evoked fields (SEFs) in 20 monozygotic (MZ) and 14 dizygotic (DZ) twin pairs. Previous electroencephalogram (EEG) studies that demonstrated a genetic contribution to evoked responses generally focused on characteristics of representative brain potentials. Here we demonstrate significantly smaller amplitude differences within MZ compared to DZ twin pairs for the complete SEF time series (across left and right hand SEFs: 0.37 vs. 0.60 pT(2) and 0.28 vs. 0.39 pT(2) for primary [SI] and secondary [SII] sensory cortex activation) and higher MZ than DZ wave shape correlations (.71 vs. .44 and .52 vs. .35 for SI and SII activation). Our findings indicate a genetic influence on MEG-recorded evoked brain activity and also confirm our recent conclusion (van 't Ent, van Soelen, Stam, De Geus, & Boomsma, 2009) that higher MZ resemblance for EEG amplitudes is not trivially reflecting greater MZ concordance in intervening biological tissues.

摘要

我们在 20 对同卵 (MZ) 和 14 对异卵 (DZ) 双胞胎中测试了对脑磁图 (MEG) 记录的体感诱发电位 (SEF) 的遗传影响。以前的脑电图 (EEG) 研究表明，诱发反应具有遗传贡献，这些研究通常集中在代表性脑电位的特征上。在这里，我们展示了同卵双胞胎内的振幅差异明显小于异卵双胞胎，对于完整的 SEF 时间序列（左手和右手 SEF 之间：0.37 对 0.60 pT(2)和 0.28 对 0.39 pT(2)，用于初级 [SI] 和次级 [SII] 感觉皮层激活）和更高的 MZ 比 DZ 波形状相关性（SI 和 SII 激活时为 0.71 对 0.44 和 0.52 对 0.35）。我们的发现表明 MEG 记录的诱发脑活动受到遗传影响，也证实了我们最近的结论（van 't Ent、van Soelen、Stam、De Geus 和 Boomsma，2009），即 EEG 幅度的更高 MZ 相似性并不是反映中间生物组织中更高的 MZ 一致性的琐碎因素。