Department of Medicine, Division of Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Immunology. 2010 Mar;129(3):311-21. doi: 10.1111/j.1365-2567.2009.03240.x.
Interleukin-17 (IL-17) has emerged as a central player in the mammalian immune system. Although this cytokine exerts a host-defensive role in many infectious diseases, it promotes inflammatory pathology in autoimmunity and other settings. A myriad of studies have focused on how IL-17-producing cells are generated. However, the means by which IL-17 achieves its effects, either for the benefit or the detriment of the host, are due in large part to the induction of new gene expression. Whereas many IL-17 target genes are common to different disease states, in some cases the effects of IL-17 differ depending on the target cell, infectious site or pathogen. Gene products induced by IL-17 include cytokines (IL-6, granulocyte-colony-stimulating factor, tumour necrosis factor-alpha), chemokines (CXCL1, CXCL2, CCL20, among many others), inflammatory effectors (acute-phase protesins, complement) and antimicrobial proteins (defensins, mucins). Different cell types appear to respond differently to IL-17 in terms of target gene expression, with notable differences seen in mesenchymal and epithelial cells compared with cells of haematopoietic origin. Here, we summarize the major IL-17 target genes that mediate this cytokine's activities in both autoimmune and chronic diseases as well as during various types of infections.
白细胞介素-17（IL-17）已成为哺乳动物免疫系统的核心成员。尽管这种细胞因子在许多传染病中发挥宿主防御作用，但它在自身免疫和其他情况下促进炎症病理学。大量研究集中在产生产生白细胞介素-17 的细胞的方式上。然而，白细胞介素-17 实现其效应的方式，无论是对宿主有利还是有害，在很大程度上取决于新基因表达的诱导。虽然许多白细胞介素-17 的靶基因在不同的疾病状态中是共同的，但在某些情况下，白细胞介素-17 的作用因靶细胞、感染部位或病原体而异。白细胞介素-17 诱导的基因产物包括细胞因子（IL-6、粒细胞集落刺激因子、肿瘤坏死因子-α）、趋化因子（CXCL1、CXCL2、CCL20 等）、炎症效应物（急性期蛋白、补体）和抗菌蛋白（防御素、粘蛋白）。不同的细胞类型似乎在靶基因表达方面对白细胞介素-17 的反应不同，与造血细胞相比，间充质和上皮细胞表现出明显的差异。在这里，我们总结了主要的白细胞介素-17 靶基因，这些基因介导了这种细胞因子在自身免疫和慢性疾病以及各种类型感染中的活性。
