Hurme M, Lahdenpohja N, Santtila S
Department of Microbiology and Immunology, University of Tampere and Tampere University Hospital, Finland.
Ann Med. 1998 Oct;30(5):469-73. doi: 10.3109/07853899809002488.
Cytokines are proteins that regulate immune and inflammatory reactions as well as haematopoiesis. This group of molecules is very heterogeneous including, for example, several interleukins (IL), tumour necrosis factors (TNF) and colony-stimulating factors (CSF). The cytokines participating in the regulation of the inflammatory response are IL-1, IL-1 receptor antagonist (IL-1RA), IL-6, IL-10 and TNF. Functionally they can be divided into proinflammatory (IL-1, IL-6, TNF) and anti-inflammatory (IL-1RA, IL-10) molecules. There is evidence that the inflammatory response must be finely tuned: too strong a response causes the various adverse effects associated with infectious and autoimmune diseases, while a weak inflammatory response attenuates the subsequent immune response. It has now been demonstrated that several of the cytokine genes are polymorphic. In this review we describe the polymorphisms of the two inflammatory cytokines, IL-1 and IL-10, and their significance in various diseases of autoimmune or inflammatory nature.
细胞因子是一类调节免疫反应、炎症反应以及造血作用的蛋白质。这组分子具有高度的异质性，包括多种白细胞介素（IL）、肿瘤坏死因子（TNF）和集落刺激因子（CSF）等。参与炎症反应调节的细胞因子有IL-1、IL-1受体拮抗剂（IL-1RA）、IL-6、IL-10和TNF。从功能上它们可分为促炎分子（IL-1、IL-6、TNF）和抗炎分子（IL-1RA、IL-10）。有证据表明，炎症反应必须得到精确调节：过强的反应会引发与感染性疾病和自身免疫性疾病相关的各种不良反应，而较弱的炎症反应则会削弱后续的免疫反应。现已证明，几种细胞因子基因具有多态性。在本综述中，我们描述了两种炎症细胞因子IL-1和IL-10的多态性及其在各种自身免疫性或炎症性疾病中的意义。
