School of Population Health, University of Queensland, Herston, Qld, Australia.
Trop Med Int Health. 2010 Feb;15(2):198-207. doi: 10.1111/j.1365-3156.2009.02440.x.
To determine spatial patterns of co-endemicity of schistosomiasis mansoni and the soil-transmitted helminths (STHs) Ascaris lumbricoides, Trichuris trichiura and hookworm in the Great Lakes region of East Africa, to help plan integrated neglected tropical disease programmes in this region.
Parasitological surveys were conducted in Uganda, Tanzania, Kenya and Burundi in 28 213 children in 404 schools. Bayesian geostatistical models were used to interpolate prevalence of these infections across the study area. Interpolated prevalence maps were overlaid to determine areas of co-endemicity.
In the Great Lakes region, prevalence was 18.1% for Schistosoma mansoni, 50.0% for hookworm, 6.8% for A. lumbricoides and 6.8% for T. trichiura. Hookworm infection was ubiquitous, whereas S. mansoni, A. lumbricoides and T. trichiura were highly focal. Most areas were endemic (prevalence >or=10%) or hyperendemic (prevalence >or=50%) for one or more STHs, whereas endemic areas for schistosomiasis mansoni were restricted to foci adjacent large perennial water bodies.
Because of the ubiquity of hookworm, treatment programmes are required for STH throughout the region but efficient schistosomiasis control should only be targeted at limited high-risk areas. Therefore, integration of schistosomiasis with STH control is only indicated in limited foci in East Africa.
确定东非大湖地区曼氏血吸虫病和土源性蠕虫（蛔虫、鞭虫和钩虫）共流行的空间模式，以帮助该地区规划综合的被忽视热带病规划。
在乌干达、坦桑尼亚、肯尼亚和布隆迪的 404 所学校对 28213 名儿童进行了寄生虫学调查。采用贝叶斯地统计模型对这些感染在研究区域内的流行程度进行插值。对插值后的流行地图进行叠加，以确定共流行区域。
在大湖地区，曼氏血吸虫病的流行率为 18.1%，钩虫为 50.0%，蛔虫为 6.8%，鞭虫为 6.8%。钩虫感染无处不在，而曼氏血吸虫病、蛔虫和鞭虫则高度集中。大多数地区（流行率>或=10%）或高度流行（流行率>或=50%）一种或多种土源性蠕虫，而曼氏血吸虫病的流行地区仅限于与大型常年水体相邻的焦点。
由于钩虫的普遍性，整个地区都需要进行土源性蠕虫治疗方案，但只有在有限的高风险地区才能有效控制血吸虫病。因此，在东非，血吸虫病与土源性蠕虫病控制的整合仅在有限的焦点地区是合适的。
