Department of Biochemistry and Molecular Biology, Primeasia University, Dhaka, Bangladesh.
Department of Biochemistry and Molecular Biology, Faculty of Life Science, Mawlana Bhashani Science and Technology University, Tangail, Bangladesh.
Cancer Med. 2023 Jul;12(13):14556-14583. doi: 10.1002/cam4.5984. Epub 2023 May 3.
The most common and deadly cancer in female is breast cancer (BC) and new incidence and deaths related to this cancer are rising.
Several issues, that is, high cost, toxicity, allergic reactions, less efficacy, multidrug resistance, and the economic cost of conventional anti-cancer therapies, has prompted scientists to discover innovative approaches and new chemo-preventive agents.
Numerous studies are being conducted on plant-based and dietary phytochemicals to discover new-fangled and more advanced therapeutic approaches for BC management.
We have identified that natural compounds modulated many molecular mechanisms and cellular phenomena, including apoptosis, cell cycle progression, cell proliferation, angiogenesis and metastasis, up-regulation of tumor-suppressive genes, and down-regulation of oncogenes, modulation of hypoxia, mammosphere formation, onco-inflammation, enzymatic regulation, and epigenetic modifications in BC. We found that a number of signaling networks and their components such as PI3K/Akt/mTOR, MMP-2 and 9, Wnt/-catenin, PARP, MAPK, NF-κB, Caspase-3/8/9, Bax, Bcl2, Smad4, Notch1, STAT3, Nrf2, and ROS signaling can be regulated in cancer cells by phytochemicals. They induce up-regulation of tumor inhibitor microRNAs, which have been highlighted as a key player for ani-BC treatments followed by phytochemical supplementation.
Therefore, this collection offers a sound foundation for further investigation into phytochemicals as a potential route for the development of anti-cancer drugs in treating patients with BC.
女性最常见和最致命的癌症是乳腺癌（BC），与这种癌症相关的新发病例和死亡人数正在上升。
一些问题，即高成本、毒性、过敏反应、疗效较低、多药耐药性以及传统抗癌疗法的经济成本，促使科学家们发现创新方法和新的化学预防剂。
正在对植物源性和饮食植物化学物质进行大量研究，以发现用于管理乳腺癌的新的、更先进的治疗方法。
我们已经确定，天然化合物调节了许多分子机制和细胞现象，包括细胞凋亡、细胞周期进展、细胞增殖、血管生成和转移、肿瘤抑制基因的上调和癌基因的下调、缺氧的调节、乳腺球形成、癌性炎症、酶调节和表观遗传修饰。我们发现，许多信号网络及其组成部分，如 PI3K/Akt/mTOR、MMP-2 和 9、Wnt/-catenin、PARP、MAPK、NF-κB、Caspase-3/8/9、Bax、Bcl2、Smad4、Notch1、STAT3、Nrf2 和 ROS 信号，可以被植物化学物质调节。它们诱导肿瘤抑制剂 microRNAs 的上调，这些 microRNAs 被认为是抗乳腺癌治疗的关键因素，随后进行植物化学物质补充。
因此，本综述为进一步研究植物化学物质作为开发治疗乳腺癌患者的抗癌药物的潜在途径提供了坚实的基础。
