解释焦虑与抑郁以及湿疹之间关联的因素：霍达兰健康研究（HUSK）。
Factors accounting for the association between anxiety and depression, and eczema: the Hordaland health study (HUSK).
作者信息
Klokk Marianne, Gotestam Karl Gunnar, Mykletun Arnstein
机构信息
Department of Adult Psychiatry, Aalesund Hospital, Helse Sunnmore HF, N-6026 Aalesund, Norway.
出版信息
BMC Dermatol. 2010 Apr 22;10:3. doi: 10.1186/1471-5945-10-3.
BACKGROUND
The association between anxiety and depression, and eczema is well known in the literature, but factors underlying this association remain unclear. Low levels of omega-3 fatty acids and female gender have been found to be associated with both depression and eczema. Somatization and health anxiety are known to be associated with anxiety and depression, further, somatization symptoms and health anxiety have also been found in several dermatological conditions. Accordingly, omega-3 fatty acid supplement, female gender, somatization and health anxiety are possible contributing factors in the association between anxiety and depression, and eczema. The aim of the study is to examine the relevance of proposed contributing factors for the association between anxiety and depression, and eczema, including, omega-3 fatty acid supplement, female gender, health anxiety and somatization.
METHODS
Anxiety and depression was measured in the general population (n = 15715) employing the Hospital Anxiety and Depression Scale (HADS). Information on eczema, female gender, omega-3 fatty acid supplement, health anxiety and somatization was obtained by self-report.
RESULTS
Somatization and health anxiety accounted for more than half of the association between anxiety/depression, and eczema, while the other factors examined were of minor relevance for the association of interest.
CONCLUSIONS
We found no support for female gender and omega-3 fatty acid supplement as contributing factors in the association between anxiety/depression, and eczema. Somatization and health anxiety accounted for about half of the association between anxiety/depression, and eczema, somatization contributed most. The association between anxiety/depression, and eczema was insignificant after adjustment for somatization and health anxiety. Biological mechanisms underlying the mediating effect of somatization are yet to be revealed.
背景
焦虑、抑郁与湿疹之间的关联在文献中已广为人知，但这种关联背后的因素仍不清楚。已发现低水平的ω-3脂肪酸和女性性别与抑郁和湿疹均有关联。躯体化和健康焦虑与焦虑和抑郁有关，此外，在几种皮肤病中也发现了躯体化症状和健康焦虑。因此，ω-3脂肪酸补充剂、女性性别、躯体化和健康焦虑可能是焦虑、抑郁与湿疹之间关联的促成因素。本研究的目的是检验所提出的促成因素与焦虑、抑郁和湿疹之间关联的相关性，包括ω-3脂肪酸补充剂、女性性别、健康焦虑和躯体化。
方法
采用医院焦虑抑郁量表（HADS）对普通人群（n = 15715）进行焦虑和抑郁测量。通过自我报告获取有关湿疹、女性性别、ω-3脂肪酸补充剂、健康焦虑和躯体化的信息。
结果
躯体化和健康焦虑占焦虑/抑郁与湿疹之间关联的一半以上，而所研究的其他因素与该关联的相关性较小。
结论
我们发现女性性别和ω-3脂肪酸补充剂并非焦虑/抑郁与湿疹之间关联的促成因素。躯体化和健康焦虑约占焦虑/抑郁与湿疹之间关联的一半，其中躯体化的作用最大。在对躯体化和健康焦虑进行调整后，焦虑/抑郁与湿疹之间的关联不显著。躯体化介导作用的生物学机制尚待揭示。
Zotero 插件